Results 101 to 110 of about 583,131 (293)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Global Survey of Companion Animal Veterinary Practitioners on Animal Welfare Teaching – focus on undergraduate and continuing education, and clients’ sources of information [PDF]
As part of a wider research on animal welfare, a global survey was developed to gain insight into the opinion of companion animal veterinarians about animal welfare education, namely to investigate i) their exposure to animal welfare teaching during ...
van Lith, Hein +2 more
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AnimalsFree-roaming cats in urban and peri-urban areas and in rural towns pose significant challenges due to their nuisance behaviors, threats to wildlife, and potential disease transmission. Traditional management methods often involve trapping and euthanizing
Jacquie Rand +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Functional community for welfare of Promote community welfare
, 2005 publisher青森市国立情報学研究所の「学術雑誌公開支援事業」により電子化されました。2000年6月に成立した社会福祉法は、我が国の社会福祉パラダイムを地域福祉の推進と規定した。個別地域社会において、地域福祉を推進していく上に、「福祉コミュニティ」の形成は不可欠である。本研究では、地域福祉の歴史、背景を考察し、地域福祉政策も福祉コミュニティづくりの理念と方向を持つものであることを考察した。さらに、先行研究の地域福祉概念や構成要件をレビューした。その結果、地域福祉は ...
大和田, 猛 +2 more
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State self-earned income and welfare provision in China [PDF]
, 2002 Local governments in China in the 1990s relied increasingly on self-earned income, but little is known about the impact of this on the provision of public goods, especially in wealthy urban areas.
Duckett, J.
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Historical Trust Levels Predict Current Welfare State Design [PDF]
Using cross-sectional data for 76 countries, we apply instrumental variable techniques based on pronoun drop, temperature and monarchies to demonstrate that historical trust levels predict several indicators of current welfare state design, including ...
Bjørnskov, Christian, Bergh, Andreas
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AnimalsCurrent cat management approaches are outdated and ineffective, failing to reduce stray cat numbers or related complaints and negatively impacting the job satisfaction and mental health of veterinary, shelter, and municipal staff.
Jacquie Rand +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source