Results 41 to 50 of about 6,923,116 (257)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

#238 : rsERT Guided Personalized Embryo Transfer Improves Clinical Outcomes in RIF Patients

Fertility & Reproduction, 2023
Background and Aims: Narrowed or shifted window of implantation (WOI) is acknowledged to be one of the endometrial origins of embryo implantation failure, especially in patients with repeated implantation failure (RIF).
Sijia Lu
doaj   +1 more source

Unexplained infertility: overall ongoing pregnancy rate and mode of conception

, 2010
Item does not contain fulltextBACKGROUND: Unexplained infertility is one of the most common diagnoses in fertility care. The aim of this study was to evaluate the outcome of current fertility management in unexplained infertility.
M. Brandes, J. P. de Bruin, Brandes, M., W. L. D. M. Nelen, Bruin, J.P. de, Kremer, J.A.M., Hamilton, C.J.C.M., J. O. M. van der Steen, J. A. M. Kremer, Nelen, W.L.D.M., Steen, J.O. van der, Bots, R.S., C. J. C. M. Hamilton, R. S. G. M. Bots   +13 more
core   +1 more source

Additional file 5 of Longitudinal surface measurements of human blastocysts show that the dynamics of blastocoel expansion are associated with fertilization method and ongoing pregnancy

, 2022
Additional file 5. Linear mixed model analysis of blastocystexpansion surface measurements over time and expansion rate, of fresh embryotransfers (SET and DET resulting in either no ongoing pregnancy or a twinongoing pregnancy) compared between IVF, ICSI
Régine P. M. Steegers-Theunissen (11452452), Maria P. H. Koster (9656858), Esther B. Baart (11452449), Effrosyni A. Chavli (12264951), Joop S. E. Laven (8538123), Eva S. van Marion (11452446)   +5 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Forest plot of pregnancy and miscarriage rates for GnRH long agonist protocol versus GnRH antagonist protocol.

, 2014
(A) Clinical pregnancy rate. (B) Ongoing pregnancy rate.
Lin Li (28817), Dongzi Yang (468047), Wenjun Wang (314231), Qingxue Zhang (538934), Haiyan Lin (116227), Yu Li (183836)   +5 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Administration of single-dose GnRH agonist in the luteal phase in ICSI cycles: a meta-analysis

Reproductive Biology and Endocrinology, 2010
Background The effects of gonadotrophin-releasing hormone agonist (GnRH-a) administered in the luteal phase remains controversial. This meta-analysis aimed to evaluate the effect of the administration of a single-dose of GnRH-a in the luteal phase on ...
Oliveira João, Baruffi Ricardo, Petersen Cláudia G, Mauri Ana L, Cavagna Mario, Franco José G   +5 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Incidence of pregnancy outcomes among patients with recurrent implantation failure: a systematic review and meta-analysis

BMC Pregnancy and Childbirth
Background Globally, there is no conclusive data on the pregnancy outcomes of patients with recurrent implantation failure (RIF) who received the next embryo transfer.
Yunan He, Shaole Shi, Xiaoxiao Su, Ge Chen, Xiexiong Zhao   +4 more
doaj   +1 more source