Results 61 to 70 of about 13,131,942 (338)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

‘Indirect Feedback’

open access: yesHigher Learning Research Communications, 2019
Whilst there is consensus in the current literature that feedback plays a fundamental role to student performance and learning, there is also debate about what makes it effective.
Ricardo Tejeiro   +3 more
doaj   +1 more source

Religiously-Motivated Medical Neglect: A Response to Professors Levin, Jacobs, and Arora [PDF]

open access: yes, 2016
This Response to Professors Levin, Jacobs, and Arora’s article To Accommodate or Not to Accommodate: (When) Should the State Regulate Religion to Protect the Rights of Children and Third Parties?
Coleman, Doriane Lambelet
core   +2 more sources

Online Coded Caching

open access: yes, 2013
We consider a basic content distribution scenario consisting of a single origin server connected through a shared bottleneck link to a number of users each equipped with a cache of finite memory.
Maddah-Ali, Mohammad Ali   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Outcomes and complication rates of different materials used for nasal dorsal augmentation in septorhinoplasty: a systematic review and meta-analysis

open access: yesThe Egyptian Journal of Otolaryngology
Autologous materials and alloplastic implants are commonly used in dorsal augmentation of septorhinoplasty (SRP). So far, there is no satisfactory evidence to ascertain the safest, efficient, and superior aesthetic outcomes among different materials ...
Amr Gouda Shafik   +16 more
doaj   +1 more source

Online supervised hashing [PDF]

open access: yes, 2017
Fast nearest neighbor search is becoming more and more crucial given the advent of large-scale data in many computer vision applications. Hashing approaches provide both fast search mechanisms and compact index structures to address this critical need ...
Bargal, Sarah Adel   +2 more
core   +1 more source

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