Results 71 to 80 of about 13,131,942 (338)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
EURODL, 2020 The self-determination of online graduate students was studied in terms of the impact of autonomy, competence and relatedness upon their persistence. Unique to this study was the assessment of the potential influence of socio-cultural factors.
Charmaine Bissessar +2 more
doaj +1 more source
, 2007 Presents findings from a telephone survey conducted in 2006, and demonstrates that Hispanics with lower levels of education and English proficiency remain largely disconnected from the ...
Gretchen Livingston, Susannah Fox
core
, 2018 Approximate nearest neighbor (ANN) search has achieved great success in many tasks. However, existing popular methods for ANN search, such as hashing and quantization methods, are designed for static databases only.
Tsang, Ivor W., Xu, Donna, Zhang, Ying
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A step-by-step guide for conducting an umbrella review
Tropical Medicine and HealthBackground The rapid increase in published research poses challenges for healthcare professionals aiming to stay updated. While systematic reviews help synthesize findings, their abundance can overwhelm readers.
Mohammed Abdellatif +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Journal of Information Systems Engineering and Business Intelligence, 2019 Background: Given the digital transformation in currently emerging digital era in Financial Service Industry; marked by the rise of Fintech; Financial Service Authority (FSA) is challenged to mitigate new type of risks that are introduced by it. As first
Dina Fitria Murad +4 more
doaj +1 more source