Results 31 to 40 of about 9,740,724 (300)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

How Could Semantic Processing and Other NLP Tools Improve Online Legal Databases?

TalTech Journal of European Studies, 2023
The spread of online databases and the increasingly sophisticated search solutions in the past 10–15 years have opened up many new opportunities for lawyers to find relevant documents.
Vági Renátó
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Tripal: a construction toolkit for online genome databases. [PDF]

, 2011
Poster presented at the 2012 Washington State University Academic Showcase.We are developing a comprehensive genomics, genetics and breeding database infrastructur basic, transaltional and applied research.Washington State University, Pullman, WA ...
S. P. Ficklin, D. Main, C.-H. Cheng, Cho, Il-Hyung, Main, Doreen, T. Lee, Cho, II-Hyung, Bett, Kirstin E, Jung, Sook, Cheng, Chun-Huai, K. E. Bett, L.-A. Sanderson, Ficklin, Stephen, Bett, Kirstin E., Staton, Margaret, Bett, Kirstin, Lee, Taein, S. Jung, Main, Dorrie, Ficklin, Stephen P, Sanderson, Lacey-Anne, Ficklin, Stephen P., Sanderson, Lacey-Ann, Staton, Margaret E, M. E. Staton, I.-H. Cho   +25 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The power of citizen science to advance fungal conservation

Conservation Letters
Fungal conservation is gaining momentum globally, but many challenges remain. To advance further, more data are needed on fungal diversity across space and time.
Danny Haelewaters, C. Alisha Quandt, Lachlan Bartrop, Jonathan Cazabonne, Martha E. Crockatt, Susana P. Cunha, Ruben De Lange, Laura Dominici, Brian Douglas, Elisandro Ricardo Drechsler‐Santos, Jacob Heilmann‐Clausen, Peter J. Irga, Sigrid Jakob, Lotus Lofgren, Thomas E. Martin, Mary Nyawira Muchane, Jeffery K. Stallman, Annemieke Verbeken, Allison K. Walker, Susana C. Gonçalves   +19 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A reassessment of Mexico’s floristic richness

Botan‪ical Sciences
Background: Since the publication of Villaseñor's floristic list of Mexico in 2016, numerous changes have occurred, reflecting the dynamism of taxonomic work.
José Luis Villaseñor, Enrique Ortiz
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source