Results 41 to 50 of about 5,251,405 (311)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Hierarchical classification for multiple, distributed web databases [PDF]
, 2004 The proliferation of online information resources increases the importance of effective and efficient distributed searching. Our research aims to provide an alternative hierarchical categorization and search capability based on a Bayesian network ...
Yang, Hui, Zhang, Minjie
core
"Spice", "Kryptonite", "Black Mamba": An overview of brand names and marketing stragtegies of Novel Psychoactive Substances on the Web [PDF]
, 2014 Novel Psychoactive Substances (NPSs) are often sold online as “legal” and “safer” alternatives to International Controlled Drugs (ICDs) with captivating marketing strategies.
Advisory Council on the Misuse of Drugs (ACMD) +10 more
core +2 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Online Predicted Human Interaction Database [PDF]
Bioinformatics, 2005 High-throughput experiments are being performed at an ever-increasing rate to systematically elucidate protein-protein interaction (PPI) networks for model organisms, while the complexities of higher eukaryotes have prevented these experiments for humans.The Online Predicted Human Interaction Database (OPHID) is a web-based database of predicted ...
Kevin R, Brown, Igor, Jurisica
openaire +2 more sources
The SOL Genomics Network Model: Making Community Annotation Work [PDF]
, 2009 The concept of community annotation is a growing discipline for achieving participation of the research community in depositing up‐to‐date knowledge in biological databases. The Solanaceae Genomics Network ("SGN":http ...
Adri Mills +9 more
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The Current State of Online Philanthropy [PDF]
, 2009 Based on an analysis of fifty-five online nonprofit databases and giving platforms, examines the range and quality of information and services provided, the providers, the users, the distribution of traffic among the sites, and areas for ...
David Koken
core
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
The power of citizen science to advance fungal conservation
Conservation LettersFungal conservation is gaining momentum globally, but many challenges remain. To advance further, more data are needed on fungal diversity across space and time.
Danny Haelewaters +19 more
doaj +1 more source