Results 101 to 110 of about 191,546 (252)
Scientific ReportsAt present, quantitative data is mainly used as the basis for service-oriented enterprise decision-making. However, a single dimension and type of analysis cannot accurately reflect the uncertainty of enterprise operations.
Mingliang Yu +3 more
doaj +1 more source
Recent Advances in Decoupling Strategies for Soft Sensors
Advanced Science, EarlyView.This review provides an overview of recent advances in decoupling strategies for soft sensors. It summarizes single‐modal sensors that are insensitive to stretching, bending, crosstalk, and other environmental interferences, and highlights emerging multimodal decoupling methods enabled by spatiotemporal information and machine learning.
Yangbo Yuan +4 more
wiley +1 more source
Advanced Science, EarlyView.This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li +7 more
wiley +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
Advanced Science, EarlyView.Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi +15 more
wiley +1 more source
Advanced Science, EarlyView.This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu +12 more
wiley +1 more source
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation
Advanced Science, EarlyView.NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi +14 more
wiley +1 more source
Advanced Science, EarlyView.Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang +11 more
wiley +1 more source
A comprehensive analysis of online patient educational materials for lichen sclerosus. [PDF]
Int J Womens DermatolFoster J, Chang HR, Mauskar MM.
europepmc +1 more source