Results 61 to 70 of about 1,549,872 (314)

Online behavior identification in distributed systems

open access: yes, 2015
The diagnosis, prediction, and understanding of unexpected behavior is crucial for long running, large scale distributed systems. However, existing works focus on the identification of faults in specific time moments preceded by significantly abnormal ...
Szabo, C.   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Online social support: an exploratory study of breastfeeding women’s use of internet and mobile applications to obtain peer support [PDF]

open access: yes, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Online social support is reported to be used by a number of people to obtain social interaction and exchange communication as a way to buffer stressful ...
Burman, Ana Beatriz Santana
core  

Effektivität und Effizienz von Online-Hilfesystemen in deutschen Universitäts-OPACs [PDF]

open access: yes, 2007
Today, almost always Online Public Access Catalogues (OPACs) are the only way to access library collections, but practical experience shows that users have problems dealing with electronic catalogues.
Greifeneder, Elke
core   +1 more source

Optimizing ranking systems online as bandits

open access: yesACM SIGIR Forum, 2021
Ranking system is the core part of modern retrieval and recommender systems, where the goal is to rank candidate items given user contexts. Optimizing ranking systems online means that the deployed system can serve users' requests, e.g., queries in the web search, and optimize the ranking policy by learning from user interactions, e.g., clicks.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Exploring personality-targeted UI design in online social participation systems [PDF]

open access: yes, 2013
We present a theoretical foundation and empirical findings demonstrating the effectiveness of personality-targeted design. Much like a medical treatment applied to a person based on his specific genetic profile, we argue that theory-driven, personality ...
López, Claudia   +11 more
core   +1 more source

Online Intrusion Detection for IoT Systems with Full Bayesian Possibilistic Clustering and Ensembled Fuzzy Classifiers

open access: yes, 2022
The pervasive deployment of the internet of things (IoT) has significantly facilitated manufacturing and living. The diversity and continual updates of IoT systems make their security a crucial challenge, among which the detection of malicious network ...
Zhao, RJ   +5 more
core   +1 more source

A First Approach to Co-Design a Multimodal Pedagogic Conversational Agent with Pre-Service Teachers to Teach Programming in Primary Education

open access: yesComputers
Pedagogic Conversational Agents (PCAs) are interactive systems that engage the student in a dialogue to teach some domain. They can have the roles of a teacher, student, or companion, and adopt several shapes. In our previous work, a significant increase
Diana Pérez-Marín   +2 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

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