Results 81 to 90 of about 1,382,662 (294)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Unraveling the Genetic Heartbeat: Decoding Cardiac Involvement in Duchenne Muscular Dystrophy

Biomedicines
Cardiomyopathy represents the most important life-limiting condition of Duchenne muscular dystrophy (DMD) patients after the age of 20. Genetic alterations in the DMD gene result in the absence of functional dystrophin protein, leading to skeletal ...
Valeria Novelli, Francesco Canonico, Renzo Laborante, Martina Manzoni, Alessandra Arcudi, Giulio Pompilio, Eugenio Mercuri, Giuseppe Patti, Domenico D’Amario   +8 more
doaj   +1 more source

Influence of mental stress on the pulse wave features of photoplethysmograms

Healthcare Technology Letters, 2019
Mental stress is a major burden for our society. Invasive and non-invasive methods have been proposed to monitor and quantify it using various sensors on and off body.
Patrick Celka, Peter H. Charlton, Peter H. Charlton, Bushra Farukh, Bushra Farukh, Philip Chowienczyk, Jordi Alastruey   +6 more
doaj   +1 more source

Soil moisture controls on patterns of grass green-up in Inner Mongolia: an index based approach [PDF]

Hydrology and Earth System Sciences, 2013
Water availability is one of the most important environmental controls on vegetation phenology, especially in semi-arid regions. It is often represented in terms of soil moisture in small-scale studies, whereas it tends to be represented by precipitation
H. Liu, F. Tian, H. C. Hu, H. P. Hu, M. Sivapalan   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

‘This you may NNNNNNEVER have heard before’: initial lengthening of accented negative items as vocal-entangled gestures

Language and Cognition
Movement scientists have proposed to ground the relation between prosody and gesture in ‘vocal-entangled gestures’, defined as biomechanical linkages between upper limb movement and the respiratory–vocal system. Focusing on spoken language negation, this
Simon Harrison
doaj   +1 more source

An 'Importance' Map of Signs and Symptoms to Classify Diabetic Polyneuropathy: An Exploratory Data Analysis. [PDF]

PLoS ONE, 2015
Early diagnosis of diabetic polyneuropathy (DPN) is critical for a good prognosis. We aimed to identify different groups of patients, based on the various common clinical signs and symptoms of DPN, that represent a progressive worsening of the disease ...
Isabel C N Sacco, Eneida Yuri Suda, Vincent Vigneron, Cristina Dallemole Sartor   +3 more
doaj   +1 more source

A Challenging Solar Eruptive Event of 18 November 2003 and the Causes of the 20 November Geomagnetic Superstorm. I. Unusual History of an Eruptive Filament

, 2013
This is the first of four companion papers, which analyze a complex eruptive event of 18 November 2003 in AR 10501 and the causes of the largest Solar Cycle 23 geomagnetic storm on 20 November 2003. Analysis of a complete data set, not considered before,
Chertok, I. M., Filippov, B. P., Grechnev, V. V., Rudenko, G. V., Slemzin, V. A., Temmer, M., Uralov, A. M.   +6 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source