Results 141 to 150 of about 3,980 (280)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Argument and Structure: Why Formal Systems Cannot Justify Ontological Authority [PDF]
This paper examines the epistemic limits of formal modelling with respect to ontological claims. While formal systems provide precise representations of structure, relations, and internal consistency, they do not determine the meaning of the concepts ...
Tappé, Jan
core
The ontological inversion: transcending adultcentrism in the concept of development for the critical deconstruction of bleak pedagogy. [PDF]
Front PsycholLuo Y, Yang X.
europepmc +1 more source
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
The Ontological Commitment of Gadamer's Conception of Play
, 2017 In this essay, I address a holistic account of the ontological commitment of Gadamer's conception of play. The analysis consists of three parts. The first is to point out that certain basic characteristics of play are in essence some characteristics of
Chan, W.W., 陳榮華
core
Human Dignity and the Metaphysical Crisis in Postmodern Ethics. [PDF]
Linacre QFrantz P, Rego F, Barbas S.
europepmc +1 more source
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
The Onto-Rhythmic Self: An Ontological Reframing of Subjectivity. [PDF]
Integr Psychol Behav SciRahimi MD.
europepmc +1 more source
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Arabian Singularity: Spiritual Materialism and Ontological Override
This chapter argues that the emergence of Islam in 7th-century Arabia was not merely the birth of a new religion, but a profound "ontological override" - a radical ontological intervention that caused a collapse of a spiritually bankrupt social order ...
Michels, Julian
core +1 more source