Results 141 to 150 of about 514,391 (335)
Integration with Ontologies [PDF]
, 2003 One of today’s hottest IT topics is integration, as bringing together information from different sources and structures is not completely solved. The approach outlined here wants to illustrate how ontologies [Gr93] could help to support the integration ...
Aguado, J. +6 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo +9 more
wiley +1 more source
An ontological analysis of some biological ontologies [PDF]
Frontiers in Genetics, 2012 The functional importance of biological entities makes their understanding, analysis, and representation essential in modern biology. Arguably, semantic representation necessary for machine interoperability is a far more difficult task than syntactic representation, necessitating conceptual schema and ontologies for in-silico biological knowledge ...
openaire +3 more sources
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Can Ontology Inform Ontologies? [PDF]
, 2009 Traditionally, since it was coined in the early 17th century by German school philosophy, the word "ontology" has been used to name a field of metaphysics as well as distinct metaphysical doctrines. Since the 1990s, the word "ontology" appears increasingly in information sciences, and likewise in fields that have been subjected to `informatisation ...
openaire +1 more source
Canadian Journal of Philosophy, 2018 Parfit denies that the introduction of reasons into our ontology is costly for his theory. He puts forth two positions to help establish the claim: the Plural Senses View and the Argument from Empty Ontology. I argue that, first, the Plural Senses View for ‘exists’ can be expanded to allow for senses which undermine his ontological claims; second, the ...
openaire +3 more sources
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Application and Role of Ontologies in Biomedical Information Retrieval Systems
مجله انفورماتیک سلامت و زیست پزشکی, 2018 Introduction: Ontologies improve the quality of information retrieval (IR). Therefore, it is important to better know the process of ontology engineering and their application in IR.
Nader Alishan Karami +3 more
doaj
BuildingsDue to its inherent complexities in the process and the dynamic interactions with external environmental factors, the construction industry is widely considered one of the most hazardous industries worldwide. With advancements in artificial intelligence (
Sonali Pandithawatta +4 more
doaj +1 more source