Results 181 to 190 of about 147,101 (317)

Utilization of Ontology to Develop Artificial Intelligence Systems in the Healthcare Industry. [PDF]

Healthc Inform Res
Parsanasab E, Ahmadipour A, Mehraeen E.
europepmc   +1 more source

Framework for a protein ontology [PDF]

, 2006
Darren A. Natale, Cecilia N. Arighi, Winona C. Barker, Judith A. Blake, Ti‐Cheng Chang, Zhang-Zhi Hu, Hongfang Liu, Barry Smith, Cathy Wu   +8 more
openalex   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Indigenous Peoples and local communities as agents of transformative change for sustainability. [PDF]

Commun Earth Environ
Reyes-García V, Nelson V, Bonilla-Moheno M, Hausner VH, Leventon J, Wheeler HC, Aksoy Z, Bates P, Carino J, Dabezies JM, Frantzeskaki N, Gordon E, Gosnell H, Guibal C, Gurung J, Heatta MJ, Hernandez Y, Huambachano M, Ifejika Speranza C, A Magris R, Mannetti L, Mansur AV, Nishi M, O'Brien K, Pictou S, Raab K, Roskruge N, Sulyandziga R, Villasante S.   +28 more
europepmc   +1 more source

The Literary Theme Ontology for Media Annotation and Information Retrieval [PDF]

, 2019
Paul Sheridan, Mikael Onsjö, Janna Hastings   +2 more
openalex   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

The Ontology of Adverse Events in 2025. [PDF]

Sci Data
Pan C, Yang Q, Zhang X, Luo S, He Y, Xie J.   +5 more
europepmc   +1 more source

Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis

Advanced Science, EarlyView.
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu, Kexing Li, Yuge Wang, Hongyu Li, Hongyu Zhao   +4 more
wiley   +1 more source

Ontological Arguments [PDF]

The Philosophers' Magazine, 2019
openaire   +1 more source