Results 241 to 250 of about 373,534 (285)
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang+17 more
wiley +1 more source
Integrating and retrieving learning analytics data from heterogeneous platforms using ontology alignment: Graph-based approach. [PDF]
Musa MH+6 more
europepmc +1 more source
Genomic Insights into Post‐Domestication Expansion and Selection of Body Size in Ponies
The authors’ research delves into the history of ponies by assembling a pony genome and integrating horse genomes. This unveils genetic connections between Asian and European pony breeds. Cis‐regulatory elements of key genes impacting body size are also identified.
Xingzheng Li+23 more
wiley +1 more source
Understanding ecological systems using knowledge graphs: an application to highly pathogenic avian influenza. [PDF]
Robertson H+7 more
europepmc +1 more source
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu+19 more
wiley +1 more source
Mining functional gene modules by multi-view NMF of phenome-genome association. [PDF]
Jin X+8 more
europepmc +1 more source
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu+11 more
wiley +1 more source
Melatonin influence on miRNA expression in sperm, hypothalamus, pre-frontal cortex and cerebellum of Wistar rats. [PDF]
Ferro MHDS+6 more
europepmc +1 more source
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang+16 more
wiley +1 more source
Stress management with HRV following AI, semantic ontology, genetic algorithm and tree explainer. [PDF]
Chatterjee A+3 more
europepmc +1 more source