Results 251 to 260 of about 373,534 (285)

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Towards an ontology of mental health: Protocol for developing an ontology to structure and integrate evidence regarding anxiety, depression and psychosis. [PDF]

Wellcome Open Res
Schenk PM, Hastings J, Santilli M, Potts J, Kennett J, Friedrich C, Michie S.   +6 more
europepmc   +1 more source

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

Advanced Science, EarlyView.
Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah   +7 more
wiley   +1 more source

Expanding the concept of ID conversion in TogoID by introducing multi-semantic and label features. [PDF]

J Biomed Semantics
Ikeda S, Aoki-Kinoshita KF, Chiba H, Goto S, Hosoda M, Kawashima S, Kim JD, Moriya Y, Ohta T, Ono H, Takatsuki T, Yamamoto Y, Katayama T.   +12 more
europepmc   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

Erratum: Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models. [PDF]

iScience
Kain BN, Tran BT, Luna PN, Cao R, Le DT, Florez MA, Maneix L, Toups JD, Morales-Mantilla DE, Koh S, Han H, Jaksik R, Huang Y, Catic A, Shaw CA, King KY.   +15 more
europepmc   +1 more source

Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of the Dezhou donkey, encompassing 20 tissues and 275 050 cells, is constructed. Through cross‐species and cross‐tissue analyses, distinct transcriptional patterns in donkey sebocytes are identified.
Yu Tian, Shuqin Liu, Hongtao Shi, Jianjun Li, Xinglong Wan, Yujiang Sun, Huayun Li, Ning Cao, Zhixi Feng, Teng Zhang, Junjie Wang, Wei Shen   +11 more
wiley   +1 more source

Molecular characterization of the heterogeneity of satellite cell populations isolated from an individual Turkey pectoralis major muscle. [PDF]

Front Physiol
Yu H, Li Z, Yimiletey J, Wan C, Velleman S.   +4 more
europepmc   +1 more source

Energy evolution and damage ontology modeling of coal destruction at different water contents. [PDF]

PLoS One
Yu Y, Liu J, Guo W, Song Z, Yang Y, Zhao S, Xu D, Wu Z.   +7 more
europepmc   +1 more source

ACT2.6: Global Gene Coexpression Network in <i>Arabidopsis thaliana</i> Using WGCNA. [PDF]

Genes (Basel)
Zogopoulos VL, Papadopoulos K, Malatras A, Iconomidou VA, Michalopoulos I.   +4 more
europepmc   +1 more source