Results 81 to 90 of about 950,377 (347)

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

Working with Ontologies

open access: yes, 2016
Ontologies are powerful and popular tools to encode data in a structured format and manage knowledge. A large variety of existing ontologies offer users access to biomedical knowledge. This chapter contains a short theoretical background of ontologies and introduces two notable examples: The Gene Ontology and the ontology for Biological Pathways ...
Kramer, Frank, Beißbarth, Tim
openaire   +5 more sources

Ontology localization

open access: yesProceedings of the fifth international conference on Knowledge capture, 2009
nternational organizations (e.g., FAO1 , WHO2 , etc.) are increasingly expressing the need for multilingual ontologies for di®erent purposes, e.g., ontology-based multilingual machine translation, multilingual informa- tion retrieval. However, most of the ontologies built so far have mainly English or another natural language as basis.
Espinoza Mejía, Mauricio   +2 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Ontology: Towards a new synthesis [PDF]

open access: yes, 1998
This introduction to the second international conference on Formal Ontology and Information Systems presents a brief history of ontology as a discipline spanning the boundaries of philosophy and information science.
Smith, Barry, Welty, Chris
core  

Natural Language and its Ontology [PDF]

open access: yes, 2019
This paper gives a characterization of the ontology implicit in natural language and the entities it involves, situates natural language ontology within metaphysics, and responds to Chomskys' dismissal of externalist ...
Moltmann, Friederike
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Ontology (Science) [PDF]

open access: yes, 2008
Increasingly, in data-intensive areas of the life sciences, experimental results are being described in algorithmically useful ways with the help of ontologies.
Barry Smith
core   +2 more sources

Analogicity in Computer Science. Methodological Analysis

open access: yesStudies in Logic, Grammar and Rhetoric, 2020
Analogicity in computer science is understood in two, not mutually exclusive ways: 1) with regard to the continuity feature (of data or computations), 2) with regard to the analogousness feature (i.e.
Stacewicz Paweł
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

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