Results 81 to 90 of about 885,759 (298)
Ontologies for the study of neurological disease [PDF]
, 2012 We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of ...
Cox, Alexander P. +7 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Rethinking rules and social practices. The design of urban spaces in the post-Covid-19 lockdown
TeMA: Journal of Land Use, Mobility and Environment, 2020 In the last months a pandemic has changed the daily life of billions of people. Among the efforts to reduce the impact of the disease, social distancing has had huge consequences and raised may concerns, from the inadequacy of contemporary urban design ...
Maria Rosaria Stufano Melone +1 more
doaj +1 more source
Evaluating Knowledge Representation and Reasoning Capabilites of Ontology Specification Languages [PDF]
, 2000 The interchange of ontologies across the World Wide Web (WWW) and the cooperation among heterogeneous agents placed on it is the main reason for the development of a new set of ontology specification languages, based on new web standards such as XML or ...
Corcho, Oscar, Gómez-Pérez, A.
core +3 more sources
An ontology for software component matching [PDF]
, 2007 Matching is a central activity in the discovery and assembly of reusable software components. We investigate how ontology technologies can be utilised to support software component development.
Pahl, Claus
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Zagadnienia Filozoficzne w Nauce, 2020 Starting from logical structures of classical and quantum mechanics we reconstruct the logic of so-called no-signaling theories, where the correlations among subsystems of a composite system are restricted only by a simplest form of causality forbidding ...
Marek Kuś
doaj
Analogicity in Computer Science. Methodological Analysis
Studies in Logic, Grammar and Rhetoric, 2020 Analogicity in computer science is understood in two, not mutually exclusive ways: 1) with regard to the continuity feature (of data or computations), 2) with regard to the analogousness feature (i.e.
Stacewicz Paweł
doaj +1 more source