Results 81 to 90 of about 910,309 (299)
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Challenges in Reconciling Different Views of Neuroanatomy in a Reference Ontology of Anatomy [PDF]
, 2007 A fundamental requirement for integrating neuroscience data is a well-structured ontology that can incorporate, accommodate and reconcile different neuroanatomical views.
Brinkley, James F +3 more
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Rethinking rules and social practices. The design of urban spaces in the post-Covid-19 lockdown
TeMA: Journal of Land Use, Mobility and Environment, 2020 In the last months a pandemic has changed the daily life of billions of people. Among the efforts to reduce the impact of the disease, social distancing has had huge consequences and raised may concerns, from the inadequacy of contemporary urban design ...
Maria Rosaria Stufano Melone +1 more
doaj +1 more source
Facets, Tiers and Gems: Ontology Patterns for Hypernormalisation [PDF]
, 2017 There are many methodologies and techniques for easing the task of ontology building. Here we describe the intersection of two of these: ontology normalisation and fully programmatic ontology development.
Lord, Phillip, Stevens, Robert
core +1 more source
Uberon: towards a comprehensive multi-species anatomy ontology [PDF]
, 2009 The lack of a single unified species-neutral ontology covering the anatomy of a variety of metazoans is a hindrance to translating model organism research to human health.
Chris Mungall +3 more
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
OntoMaven: Maven-based Ontology Development and Management of Distributed Ontology Repositories [PDF]
, 2013 In collaborative agile ontology development projects support for modular reuse of ontologies from large existing remote repositories, ontology project life cycle management, and transitive dependency management are important needs.
Paschke, Adrian
core
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Zagadnienia Filozoficzne w Nauce, 2020 Starting from logical structures of classical and quantum mechanics we reconstruct the logic of so-called no-signaling theories, where the correlations among subsystems of a composite system are restricted only by a simplest form of causality forbidding ...
Marek Kuś
doaj