Results 41 to 50 of about 62,364 (264)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Constructing and Using the Portrait Sitting as an Art-Historical Research Object
Aesthetic Investigations, 2023 Portraiture is said to have evolved from a collaborative social practice to an artist-centric one. I challenge this view by focusing on the portrait sitting. I develop a portrait-sitting ontology, and a portrait-sitting database.
Dawn Kanter
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ontologies and Software Engineering [PDF]
, 2007 This paper is about using ontologies to identify the objects from a problem domain text description. At the center of object models and ontologies are objects within a given problem domain is similar to the concept provided by ontologies. This paper addresses ontologies as a basis of a methodology for object modeling, including available tools ...
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Information, 2023 Personal Information Management Systems (PIMS) are acquiring a prominent role in the data economy by promoting services that help individuals to have more control over the processing of their personal data, in line with the European data protection laws.
Marcu Florea, Beatriz Esteves
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Reference Architecture for Ontology Engineering Web Environments
Journal of Computer Science and Technology, 2019 Ontology authoring, maintenance and use are never easy tasks, mostly due to the complexity of real domains and how they dynamically change as well as different background possessed by modellers about methodologies and formal languages.
German Alejandro Braun +2 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Ontology for Technical Debt in Systems Engineering
IEEE Open Journal of Systems Engineering, 2023 The technical debt metaphor is used to describe the long-term consequences of engineering decisions made to achieve a short-term benefit. The metaphor originated in the field of software engineering and has begun to migrate to other fields, including ...
Howard Kleinwaks +2 more
doaj +1 more source