Results 101 to 110 of about 134,903 (295)
Advanced Healthcare Materials, EarlyView.Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum +5 more
wiley +1 more source
How do Ontology Mappings Change in the Life Sciences? [PDF]
, 2012 Mappings between related ontologies are increasingly used to support data integration and analysis tasks. Changes in the ontologies also require the adaptation of ontology mappings.
Gross, Anika +3 more
core
Advanced Healthcare Materials, EarlyView.A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen +6 more
wiley +1 more source
Information, 2018 Today, there is a rapid increase of the available data because of advances in information and communications technology. Therefore, many mutually heterogeneous data sources that describe the same domain of interest exist. To facilitate the integration of
Marko Gulić +2 more
doaj +1 more source
The Information-Flow Approach to Ontology-Based Semantic Integration
, 2010 In this article we argue for the lack of formal foundations for ontology-based semantic alignment. We analyse and formalise the basic notions of semantic matching and alignment and we situate them in the context of ontology-based alignment in open-ended ...
Kalfoglou, Yannis, Schorlemmer, Marco
core
Automatizing the Evaluation of Model Matching Systems [PDF]
, 2010 International audienceModel-Driven Engineering (MDE) and the Semantic Web are valuable paradigms. This paper sketches how to use a scientific and technical result around MDE in the Semantic Web.
Garcés, Kelly +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source
Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues
Advanced Materials, EarlyView.A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad +6 more
wiley +1 more source
Journal of Biomedical Semantics, 2011 Background Ontologies are increasingly used to structure and semantically describe entities of domains, such as genes and proteins in life sciences. Their increasing size and the high frequency of updates resulting in a large set of ontology versions ...
Kirsten Toralf +3 more
doaj +1 more source
Axiom-based ontology matching: a method and an experiment [PDF]
, 2006 Managing multiple ontologies is now a core question in most of the applications that require semantic interoperability. The Semantic Web is surely the most significant application of this report: the current challenge is not to design, develop and deploy
Furst, Frederic, Trichet, Francky
core +1 more source