Results 171 to 180 of about 1,139,414 (359)

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

open access: yesAdvanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu   +8 more
wiley   +1 more source

METHODS, APPROACHES, PRINCIPLES, GUIDELINES AND APPLICATIONS ON MULTILINGUAL ONTOLOGIES: A SURVEY

open access: yesICTACT Journal on Soft Computing, 2016
Ontologies are used in various domains to provide meaningful knowledge from data. The data can be in different natural languages. Ontologies with a lexical layer in different natural languages are needed essential to access the multilingual data by the ...
Ravi Lourdusamy, Joseph Merlin Florrence
doaj  

Improving Ontology Matching Using Meta-level Learning

open access: bronze, 2009
Kai Eckert   +2 more
openalex   +1 more source

OM4OV: Leveraging Ontology Matching for Ontology Versioning

open access: yes
Due to the dynamic nature of the Semantic Web, version control is necessary to capture time-varying information, particularly for widely used ontologies. Despite the long-standing recognition of ontology versioning (OV) as a crucial component for efficient ontology management, the growing size of ontologies and accumulating errors caused by manual ...
Qiang, Zhangcheng   +2 more
openaire   +2 more sources

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

open access: yesAdvanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan   +11 more
wiley   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

open access: yesAdvanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong   +19 more
wiley   +1 more source

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

open access: yesAdvanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie   +8 more
wiley   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

open access: yesAdvanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang   +8 more
wiley   +1 more source

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

open access: yesAdvanced Science, EarlyView.
Neoeriocitrin enhances osteogenesis in hDPSCs and bone regeneration by targeting Beclin1 to inhibit ubiquitination‐mediated degradation, thereby stabilizing Beclin1 and increasing its protein abundance to activate autophagy. Abstract Human dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation ...
Yu Wu   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy