Results 91 to 100 of about 200,095 (308)

Influência das gonadotrofinas na regulação da maturação nuclear de oócitos eqüinos Influence of gonadotropins on nuclear maturation of equine oocytes

Ciência Rural, 1998
A maturação in vitro, fecundação e as técnicas de cultivo de embriões na espécie eqüina são extremamente importantes e necessárias para se examinar as causas de repetição de cio, redução de concepção em éguas velhas e também para a preservação da espécie
Juan Manuel Larre Borges, Mara Iolanda Batistella Rubin, Carlos Antonio Mondino Silva, Paulo Bayard Dias Gonçalves, Ana Cristina Rieck   +4 more
doaj   +1 more source

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman, Carli M. Tops, Jelmer Legebeke, Ting Yang, Marcos Díaz Gay, Diantha Terlouw, Lisa E. E. L. O. Lashley, Stefan Aretz, Anna K. Sommer, Mariona Terradas, Laura Valle, Richarda M. de Voer, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Maartje Nielsen   +15 more
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Identification of a component of Drosophila polar granules [PDF]

, 1988
Information necessary for the formation of pole cells, precursors of the germ line, is provided maternally and localized to the posterior pole of the Drosophila egg.
Ackerman, Larry, Barbel, Sandra, Hay, Bruce A., Jan, Lily Y., Jan, Yuh Nung   +4 more
core  

In vitro production of bovine embryos derived from individual donors in the Corral® dish [PDF]

, 2017
Background: Since the identity of the embryo is of outmost importance during commercial in vitro embryo production, bovine oocytes and embryos have to be cultured strictly per donor.
A Cebrian-Serrano, Ann Van Soom, C Carolan, C O’Neill, C O’Neill, E Wydooghe, Eline Wydooghe, EM O’Doherty, Erik Mullaart, G Vajta, Hiemke M. Knijn, I Donnay, IGF Goovaerts, J Merton, JF Hasler, JF Hasler, JHF Pontes, JS Merton, K Matsuura, L Ferry, LJ Ding, M Hoelker, M Lane, Maaike Catteeuw, ML Reed, N Gopichandran, NK Khurana, P George, PEJ Bols, PEJ Bols, R Boni, R Roover De, RB Gilchrist, S Spanos, SA Machado, SJ Dai, T Ebner, T Fujita, WG Feng   +38 more
core   +2 more sources

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

EFNA5 as an Oocyte-Derived Factor Enhances Developmental Competence by Modulating Oxidative Stress, Inflammation, and Apoptosis During In Vitro Maturation

Antioxidants
In vitro maturation (IVM) of oocytes remains suboptimal due to oxidative stress and disrupted cumulus–oocyte communication. Oocyte-derived factors (ODFs) are key mediators of this crosstalk and crucial for oocyte competence.
Xingyuan Liu, Jian Cui, Yubing Wang, Jia Hao, Yingjie Wu, Yinjuan Wang, Lei An, Jianhui Tian, Guangyin Xi   +8 more
doaj   +1 more source

Expression and localization of nitric oxide synthase isoforms during porcine oocyte growth and acquisition of meiotic competence

Czech Journal of Animal Science, 2009
Reproduction biotechnologies depend on the use of fully meiotically competent oocytes. Growing oocytes without full meiotic competence are an interesting potential source due to their quantity, but the mechanisms regulating the processes of acquisition ...
E. Chmelíková, M. Sedmíková, J. Petr, T. Kott, V. Lánská, L. Tůmová, H. Tichovská, M. Ješeta   +7 more
doaj   +1 more source

Sec6 mutations and the Drosophila exocyst complex [PDF]

, 2005
To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila. We have used these mutations to compare the phenotypes of sec6 and sec5 in the ovary and nervous system, and we find them to be ...
Denef, Natalie, Higashi, Misao E. L., Murthy, Mala, Ranjan, Ravi, Schupbach, Trudi, Schwarz, Thomas L.   +5 more
core   +2 more sources

A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster

Animal Models and Experimental Medicine, EarlyView.
This study presents the first comprehensive proteome and phosphoproteome atlas of the Chinese hamster across nine organs (heart, liver, lung, kidney, spleen, cerebral cortex, skeletal muscle, stomach, and testis or ovary). A total of 14 219 proteins were identified in the proteome, with 11 828 phosphorylated proteins and 47 122 phosphorylation sites ...
Luyao Zhang, Tao Ding, Wanjun Peng, Jie Kong, Xiaoyue Tang, Jiyu Xu, Qiaochu Wang, Zhiyi Zhang, Chunmei Shi, Yizhuo Tian, Huilan Yang, Yehong Yang, Yue Wu, Xiaoyan Liu, Jiangfeng Liu, Juntao Yang   +15 more
wiley   +1 more source