Results 121 to 130 of about 380,066 (397)

On the origin of trisomy 21 Down syndrome [PDF]

, 2008
Background: Down syndrome, characterized by an extra chromosome 21 is the most common genetic cause for congenital malformations and learning disability.
Hultén, Maj A., Iwarsson, Erik, Jonsson, Anna Maria, Papadogiannakis, Nikos, Patel, Suketu D., Tankimanova, Maira, Westgren, Magnus   +6 more
core   +2 more sources

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Predictors of pain during oocyte retrieval

Journal of Psychosomatic Obstetrics and Gynecology, 2017
Introduction: Pain during oocyte retrieval remains prevalent despite detailed and specific pain management protocols. Exploring the role of psychosocial risk factors of pain during the oocyte retrieval could identify possible targets for prevention.
Yoon Frederiksen, Mimi Y. Mehlsen, Signe M. S. Matthiesen, Robert Zachariae, Hans Jakob Ingerslev   +4 more
doaj   +1 more source

Effect of cortisol on bovine oocytes maturation and further embryonic development after in vitro fertilization [PDF]

, 2018
Dissertação de Mestrado, Engenharia Zootécnica, 07 de dezembro de 2018, Universidade dos Açores.A maturação meiótica dos ovócitos e o posterior desenvolvimento embrionário após a fertilização são importantes requisitos fisiológicos para a sobrevivência ...
Mahdy, Aya Khaled Hassan
core  

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients

Human Reproduction, 2016
Study question Can a counseling tool be developed for women desiring elective oocyte cryopreservation to predict the likelihood of live birth based on age and number of oocytes frozen? Summary answer Using data from ICSI cycles of a population of women
R. Goldman, C. Racowsky, L. Farland, S. Munné, L. Ribustello, J. Fox   +5 more
semanticscholar   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice

Cell Death Discovery
A limited number of female germ cells support reproduction in many mammals. The follicle, composed of oocytes and supporting granulosa cells, forms the basis of oogenesis.
Chi Lieu Kim Nguyen, Yumeno Kuba, Hoai Thu Le, Hossam Hassan Shawki, Natsuki Mikami, Madoka Aoki, Nanako Yasuhara, Hayate Suzuki, Saori Mizuno-Iijima, Shinya Ayabe, Yuki Osawa, Tomoyuki Fujiyama, Tra Thi Huong Dinh, Miyuki Ishida, Yoko Daitoku, Yoko Tanimoto, Kazuya Murata, Woojin Kang, Masatsugu Ema, Yuji Hirao, Atsuo Ogura, Satoru Takahashi, Fumihiro Sugiyama, Seiya Mizuno   +23 more
doaj   +1 more source

Role of Oocyte Morphological Abnormality Rates on the Embryo Development and Implantation

Gynecology Obstetrics & Reproductive Medicine, 2018
OBJECTIVE: The aim of this study was to assess the impact of some oocyte morphological abnormality rates on embryo development and implantation. STUDY DESIGN: Oocyte morphological abnormalities including oocyte size, elliptical shape, vacuole, plain ...
Bulent Emre Bilgic, Cigdem Yayla Abide, Enis Ozkaya, Tayfun Kutlu, Sule Ayla, Ilhan Sanverdi, Gulden Tunali, Erdal Yucel, Savas Kanbur   +8 more
doaj   +1 more source

Stepped vitrification technique for human ovarian tissue cryopreservation [PDF]

, 2019
The advantage of stepped vitrification (SV) is avoiding ice crystal nucleation, while decreasing the toxic effects of high cryoprotectant concentrations. We aimed to test this method for human ovarian tissue cryopreservation.
Amorin, C.A., Camboni, A., Corral, A., Dolmans, M.M., Kilbride, P., Leonel, E.C.R., Morris, John G., Risco, Ramón, Taboga, S.R., Vázquez, Marina   +9 more
core   +1 more source