Results 131 to 140 of about 380,066 (397)
Advanced Science, EarlyView.SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai +15 more
wiley +1 more source
Cell Journal, 2017 Objective: We recently demonstrated spatial regionalization of maternal transcripts and proteins within unfertilized ovine oocyte. Here, we investigated the likelihood of oocyte polarity for the first time in bovine.
Seyed Morteza Hosseini +5 more
doaj +1 more source
Low Molecular Weight mRNA Encodes a Protein That Controls Serotonin 5-HT_(1c) and Acetylcholine M_1 Receptor Sensitivity in Xenopus Oocytes [PDF]
, 1991 Serotonin 5-HT_(1c) and acetylcholine M_1 receptors activate phosphoinositidase, resulting in an increased formation of IP_3 and 1,2 diacylglycerol.
Davidson, N. +5 more
core
Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging
Aging Cell, 2015 Female reproductive capacity declines dramatically in the fourth decade of life as a result of an age‐related decrease in oocyte quality and quantity.
A. Ben-Meir +17 more
semanticscholar +1 more source
Single‐Cell Profiling: Any Scale, Any Size, All at Once
Advanced Science, EarlyView.Traditional single‐cell technologies are constrained by cellular dimension and throughput scale, in addition to its inability preserve spatial information. With recent innovations, these technologies now allow high throughput, large‐sized cell, and multi‐modal profiling of patient samples, overcoming these limitations.
Denise Goh +4 more
wiley +1 more source
Reproductive Medicine and Biology, 2016 Reactive oxygen species (ROS) are required for cellular functioning and are controlled by anti‐oxidants. The ROS influence the follicles, oocytes, endometrium, and their environment.
Manika Kala +2 more
semanticscholar +1 more source
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
Effects of endocrine-disrupting chemical exposure on zebrafish ovarian follicles [PDF]
, 2017 The process of oocyte maturation involves both nuclear and cytoplasmic events that are essential for the production of viable eggs and subsequent fertilization in sexually reproducing animals.
D\u27Angelo, Josephine +1 more
core +2 more sources
Reproductive BioMedicine Online, 2002 This paper describes the technical approach to treatment of age-related oocyte aneuploidy. Although one solution can be oocyte/embryo selection, another is represented by the nuclear transplantation procedure. The efficiency of nuclear transplantation into immature oocytes is described as a way of generating embryos, and the possibility that viable ...
Gianpiero D, Palermo +2 more
openaire +2 more sources
Both diet and gene mutation induced obesity affect oocyte quality in mice
Scientific Reports, 2016 Obesity was shown to cause reproductive dysfunctions such as reduced conception, infertility and early pregnancy loss. However, the possible effects of obesity on oocyte quality are still not fully understood. In this study we investigated the effects of
Yan-jun Hou +5 more
semanticscholar +1 more source