Results 51 to 60 of about 40,429 (263)

Supplementation of rapamycin during in vitro maturation promotes oocyte quality and subsequent embryo development in bovine

Bulletin of the National Research Centre, 2023
Background The developmental competence of oocyte derived from in vitro maturation (IVM) is significantly lower than those of oocyte matured in vivo. Rapamycin is an immunosuppressive substance and widely used to prolong the survival and preserve the ...
Hafiza Khatun, Md Rasadul Islam, Muckta Khan, Fowzia Sultana   +3 more
doaj   +1 more source

The role of Kisspeptin signaling in Oocyte maturation

Frontiers in Endocrinology, 2022
Kisspeptins (KPs) secreted from the hypothalamic KP neurons act on KP receptors (KPRs) in gonadotropin (GPN) releasing hormone (GnRH) neurons to produce GnRH.
Saeed Masumi, Eun Bee Lee, Iman Dilower, Sameer Upadhyaya, V. Praveen Chakravarthi, Patrick E. Fields, M. A. Karim Rumi   +6 more
doaj   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Winter hibernation and UCHL1-p34cdc2 association in toad oocyte maturation competence. [PDF]

PLoS ONE, 2013
Currently, it is believed that toad oocyte maturation is dependent on the physiological conditions of winter hibernation. Previous antibody-blocking experiments have demonstrated that toad ubiquitin carboxyl-terminal hydrolase L1 (tUCHL1) is necessary ...
Zhichao Kuang, Yuwei Yao, Yan Shi, Zheng Gu, Zhaogui Sun, Jiake Tso   +5 more
doaj   +1 more source

Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review

Frontiers in Cell and Developmental Biology, 2021
Oocyte developmental competence is one of the determining factors that influence the outcomes of an IVF cycle regarding the ability of a female gamete to reach maturation, be fertilized, and uphold an embryonic development up until the blastocyst stage ...
Batara Sirait, Batara Sirait, Budi Wiweko, Budi Wiweko, Budi Wiweko, Ahmad Aulia Jusuf, Dein Iftitah, R. Muharam, R. Muharam, R. Muharam   +9 more
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Rare homozygous mutation in TUBB8 associated with oocyte maturation defect-2 in a consanguineous mating family

Journal of Ovarian Research, 2020
Purpose Variations in many genes may lead to the occurrence of oocyte maturation defects. To investigate the genetic basis of oocyte maturation defects, we performed clinical and genetic analysis of a pedigree.
Qiong Xing, Ruyi Wang, Beili Chen, Lin Li, Hong Pan, Tengyan Li, Xu Ma, Yunxia Cao, Binbin Wang   +8 more
doaj   +1 more source

Tributyltin Oxide Exposure During in vitro Maturation Disrupts Oocyte Maturation and Subsequent Embryonic Developmental Competence in Pigs

Frontiers in Cell and Developmental Biology, 2021
Tributyltin oxide (TBTO), an organotin compound, has been demonstrated to have toxic effects on several cell types. Previous research has shown that TBTO impairs mouse denuded oocyte maturation. However, limited information is available on the effects of
Yue Xiao, Bao Yuan, Weiyi Hu, Jiajia Qi, Hao Jiang, Boxing Sun, Jiabao Zhang, Shuang Liang   +7 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization

Cells, 2021
Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the distribution of location. CCs are supporting cells of the oocyte that protect
Bongkoch Turathum, Er-Meng Gao, Ri-Cheng Chian   +2 more
doaj   +1 more source