Results 251 to 260 of about 15,361,986 (325)

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential. [PDF]

Medicina (Kaunas)
Petrogiannis N, Filippa M, Chatzovoulou K, Petrogiannis S, Filippas I, Grimbizis G, Kolibianakis E, Chatzimeletiou K.   +7 more
europepmc   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality. [PDF]

Reproduction
Wei C, Zeng X, Wang K, Wang M, Lei M, Zhu Z, Xu Y, Zhao Y, Yang Q, Sun Y.   +9 more
europepmc   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

An analysis of freeze-all cycles to investigate the association between elevated progesterone on day of trigger and oocyte quality. [PDF]

J Assist Reprod Genet
Benammar A, Racowsky C, Correia K, Hadchity MT, Poulain M, Pirtea P, Ayoubi JM.   +6 more
europepmc   +1 more source

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging. [PDF]

Aging Cell
Han Y, Du Z, Wu H, Zhao R, Liu J, Gao S, Zeng S.   +6 more
europepmc   +1 more source

Influence of elevation, climate, snowmelt and floral abundance on body size of solitary bees

Ecological Entomology, EarlyView.
We measured body size in bee species from a 10‐year specimen collection from Colorado sub‐alpine meadows (2450–3450 m) and tested effects of elevation and annual snowmelt, climate and floral abundance. 2 out of 4 bee species collected across a broad elevation range showed a decline in body size with higher elevations; the other two showed no effect ...
Lachlan C. Jones, Melanie R. Kazenel, Kristin Conrad, Jane E. Ogilvie, Ian K. Breckheimer, Rebecca E. Irwin   +5 more
wiley   +1 more source