Results 41 to 50 of about 261,975 (316)

Characterization of isolated late preantral and early antral equine ovarian follicles

Reproduction and Fertility
Understanding how to effectively isolate a large number of healthy follicles is essential for increasing success rates in ARTs, such as in vitro culture and cryopreservation.
Ana Normélia P Morais, Gustavo D A Gastal, Francisco L N Aguiar, Kendall A Hyde, Melba O Gastal, Laritza F Lima, Lucy V S Ñaupas, Ana Flávia B Silva, Verónica A B Becerra, Luiza Gheno, Bruna R Curcio, Carine D Corcini, Ana Paula R Rodrigues, José R Figueiredo, Antonio S Varela Jr, Eduardo L Gastal   +15 more
doaj   +1 more source

Effect of different cryopreservation extenders added with antioxidants on semen quality and in vitro embryo production efficiency in cattle

Anais da Academia Brasileira de Ciências, 2021
To evaluate the addition of antioxidants in extenders on post-thaw bovine semen quality and in vitro embryo production efficiency. Six semen samples were collected from five Holstein bulls. In the experiment I, the samples were diluted with AndroMed® and
NATALIA C. SILVA, KAREN M. LEÃO, JOÃO T. PÁDUA, THAISA C. MARQUES, FRANCISCO R.A. NETO, MARGOT A.N. DODE, ANDRIELLE T.M. CUNHA   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice

Current Biology, 2016
Summary Sister chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation in mitosis and meiosis [1]. Rec8-containing cohesin, bound to Smc3/Smc1α or Smc3/Smc1β, maintains bivalent cohesion in mammalian meiosis [2, 3, 4, 5,
S. Burkhardt, Máté Borsos, A. Szydłowska, J. Godwin, S. Williams, P. Cohen, Takayuki Hirota, M. Saitou, Kikuë Tachibana-Konwalski   +8 more
semanticscholar   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

Science, 2015
Earliest stages of human development revealed Most of our knowledge about meiosis in mammalian oocytes stems from studies of mouse oocytes. However, chromosome segregation in mouse oocytes is much more reliable than in human oocytes.
Z. Holubcová, M. Blayney, K. Elder, M. Schuh   +3 more
semanticscholar   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Effect of Alpha Lipoic Acid as an Antioxidant Supplement during In Vitro Maturation Medium on Bovine Embryonic Development

Journal of Animal Reproduction and Biotechnology, 2017
This study was conducted to investigate the effects of alpha-lipoic acid (aLA) as an antioxidant that decrease the reactive oxygen species (ROS) in bovine embryonic development.
Bahia M. S. Hassan, Xun Fang, Pantu Kumar Roy, Sang Tae Shin, Jong Ki Cho   +4 more
doaj   +1 more source

The Exploration of miRNAs From Porcine Fallopian Tube Stem Cells on Porcine Oocytes

Frontiers in Veterinary Science, 2022
Fallopian tube is essential to fertilization and embryonic development. Extracellular vesicles (EVs) from Fallopian tube containing biological regulatory factors, such as lipids, proteins and microRNAs (miRNAs) serve as the key role.
Tzu-Yen Fu, Shu-Hsuan Wang, Tzu-Yi Lin, Perng-Chih Shen, Shen-Chang Chang, Yu-Han Lin, Chih-Jen Chou, Yu-Hsiang Yu, Kuo-Tai Yang, Chao-Wei Huang, Steven W. Shaw, Steven W. Shaw, Steven W. Shaw, Shao-Yu Peng   +13 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source