Results 51 to 60 of about 4,868 (171)

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

341 Implementation of an Antimicrobial Stewardship Program in a Private Hospital: Clinical, Microbiological, and Economic Outcomes

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Outpatient parenteral antimicrobial therapy (OPAT) is a common approach to treating complex infections, offering benefits of higher patient satisfaction, reduced risk of hospital-acquired infections, and lower healthcare costs.
Manon Nitta, Danielle Helminski, Elizabeth Scruggs-Wodkowski, Sara Keller, Ronald Kendall, Amanda Blok, Lauren Gauntlett, Nicholas Henry, Allison Ranusch, Milisa Manojlovich, Molly Harrod, Sarah Krein   +11 more
doaj   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

P-1878. Intravenous Ganciclovir Administration Outcomes via an Outpatient Parenteral Antimicrobial Therapy (OPAT) Program

Open Forum Infectious Diseases
Background Intravenous (IV) ganciclovir is used in the management of herpesvirus infections including cytomegalovirus (CMV). Ganciclovir is usually administered in the inpatient setting given the need for close monitoring of hematologic and renal ...
Dhruv Patel, Ryan P Mynatt, Ashley Logan, Evelyn Villacorta Cari, A. Mansoor   +4 more
semanticscholar   +1 more source

Qualitative analysis of barriers and facilitators to healthcare engagement for people with injecting‐related invasive infections using a social ecological framework

Addiction, Volume 120, Issue 12, Page 2476-2488, December 2025.
Abstract Background and aims Injecting‐related bacterial infections are increasing in many countries. Systemic infections often require prolonged treatment. Evidence suggests that people who inject drugs who have invasive infections are less likely to complete antimicrobial treatment and have poorer outcomes than patients without a history of injecting
Lucy O. Attwood, Sophia E. Schroeder, Olga Vujovic, Andrew J. Stewardson, Joseph S. Doyle, Paul Dietze, Peter Higgs, Samantha Colledge‐Frisby   +7 more
wiley   +1 more source

Implementation of outpatient parenteral antimicrobial therapy program in the contemporary health care system: A narrative review of the evidence

Journal of Infection and Public Health
Outpatient parenteral antimicrobial therapy (OPAT) program has become an established clinical practice globally, though its implementation varies across jurisdictions. This review explores the implementation of OPAT within contemporary healthcare systems.
Solomon Ahmed Mohammed, Natasha Roberts, David Nicolás, Sean Unwin, Menino Cotta, Jason A. Roberts, Fekade B. Sime   +6 more
doaj   +1 more source

Rezafungin Utilisation in Real Life—FungiScope Results From Europe and the United States

Mycoses, Volume 68, Issue 9, September 2025.
ABSTRACT Background Rezafungin, a novel echinocandin with once‐weekly intravenous dosing, offers potential advantages for outpatient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy and safety, real‐world experience remains limited.
Ilana Reinhold, Giovanni Mori, Massimiliano Lanzafame, Alessandro Limongelli, Antonio Vena, Julia Götz, Stilla Bauernfeind, Frank Hanses, Lukas Tometten, Michael Mayer, Ansgar Rieke, Ana Soriano‐Martin, Maricela Valerio, Jose A. Vazquez, Patrick Yue, Laman Rahimli, Nijat Azimli, Ertan Sal, Jon Salmanton‐García, Natalia Vasenda, Rosanne Sprute, Jannik Stemler, Sebastian Wingen‐Heimann, Oliver A. Cornely, Danila Seidel   +24 more
wiley   +1 more source

Kinetically Limited Growth of Dendritic Tin Oxide Thin Films: a Machine Learning Study beyond the Structure Zone Diagram

Advanced Science, Volume 12, Issue 32, August 28, 2025.
This work presents a critical evaluation of the empirical Thornton's structure zone diagram, a cornerstone in predicting thin film microstructure. Through transmission electron microscopy, we observe that Sn─O thin films form nanosized dendrites, which are not expected according to the structure zone diagram.
Denis Music, Xuelian Xiao, Rami Naser, Keke Chang, Grzegorz Sadowski, Pär A. T. Olsson   +5 more
wiley   +1 more source

P-1868. Incidence of Rhabdomyolysis in Patients Receiving Daptomycin in a Community Hospital OPAT Program

Open Forum Infectious Diseases
Background Daptomycin is a favorable medication for outpatient parenteral antimicrobial therapy (OPAT) due to its low rate of serious adverse events, however one potential therapy complication is the development of rhabdomyolysis.
Allison N Cid, H. Gibson, Gretchen S. Arnoczy, Jaspaul S Jawanda, Madonna A Biritwum, Amanda Di-Majo, Anna LeViere   +6 more
semanticscholar   +1 more source

Dynamic Profiling of Cell Free Tumour DNA in Aggressive B‐Cell Lymphoma From Diagnosis to Transformation at Relapse

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Background Next generation sequencing (NGS) of cell free tumour DNA (ctDNA) provides a snapshot of lymphoma mutations correlating with tumour burden. We evaluated the ability of ctDNA to molecularly profile and track disease burden in patients with aggressive‐B‐cell lymphoma.
Mark Waltham, Jonathan Wong, Galina Polekhina, Tessa Potezny, Pranav Dorwal, Daniella Brasacchio, Belinda Maher, Aditya Tedjaseputra, Gareth P. Gregory, Stephen Opat, Jake Shortt   +10 more
wiley   +1 more source