Results 1 to 10 of about 152,158 (260)

Neuroinflammation in Primary Open-Angle Glaucoma [PDF]

Journal of Clinical Medicine, 2020
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness worldwide. Increasing evidence suggests oxidative damage and immune response defects are key factors contributing to glaucoma onset.
S. Vernazza, S. Tirendi, A. Bassi, C. Traverso, S. Saccà   +4 more
semanticscholar   +4 more sources

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. [PDF]

Journal of the American Medical Association (JAMA), 2019
Importance Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry.
M. Hauser, R. Allingham, T. Aung, Carly J. van der Heide, K. Taylor, J. Rotter, Shih-Hsiu J. Wang, Pieter W. M. Bonnemaijer, S. Williams, S. Abdullahi, K. Abu-Amero, Michael G. Anderson, S. Akafo, M. Alhassan, Ifeoma N. Asimadu, R. Ayyagari, Saydou Bakayoko, Prisca Biangoup Nyamsi, D. Bowden, W. Bromley, D. Budenz, T. Carmichael, P. Challa, Y. Chen, C. Chuka-Okosa, J. C. Cooke Bailey, V. P. Costa, D. Cruz, H. Dubiner, J. Ervin, R. Feldman, Miles J. Flamme-Wiese, D. Gaasterland, Sarah J Garnai, C. Girkin, N. Guirou, Xiuqing Guo, J. Haines, C. Hammond, L. Herndon, T. Hoffmann, C. Hulette, Abba Hydara, R. Igo, E. Jorgenson, Joyce Kabwe, N. Kilangalanga, N. Kizor-Akaraiwe, Rachel W Kuchtey, H. Lamari, Zheng Li, J. Liebmann, Yutao Liu, R. Loos, M. Melo, S. Moroi, J. Msosa, R. Mullins, Girish N. Nadkarni, A. Napo, M. Ng, H. F. Nunes, E. Obeng-Nyarkoh, A. Okeke, S. Okeke, Olusegun B. Olaniyi, O. Olawoye, Mariana B Oliveira, L. Pasquale, R. Perez-Grossmann, M. Pericak-Vance, X. Qin, M. Ramsay, S. Resnikoff, J. Richards, R. Schimiti, K. Sim, W. Sponsel, P. Svidnicki, A. Thiadens, N. Uche, C. V. van Duijn, J. P. C. de Vasconcellos, J. Wiggs, L. Zangwill, N. Risch, D. Milea, A. Ashaye, C. Klaver, R. Weinreb, Allison E. Ashley Koch, J. Fingert, C. Khor   +92 more
semanticscholar   +3 more sources

Canaloplasty in the Treatment of Open-Angle Glaucoma: A Review of Patient Selection and Outcomes [PDF]

Advances in Therapy, 2018
Canaloplasty is a relatively new non-penetrating surgery for the reduction of intraocular pressure in patients affected by glaucoma. The technique uses a microcatheter to perform a 360 º cannulation of Schlemm’s canal and leaves in place a tension suture
I. Riva, P. Brusini, F. Oddone, M. Michelessi, R. Weinreb, L. Quaranta   +5 more
semanticscholar   +4 more sources

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Nature Communications, 2021
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying ...
P. Gharahkhani, E. Jorgenson, P. Hysi, A. Khawaja, S. Pendergrass, Xikun Han, Jue-Sheng Ong, A. Hewitt, A. Segrè, J. Rouhana, Andrew R. Hamel, R. Igo, H. Choquet, Ayub Qassim, N. Josyula, J. C. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana I. Iglesias, O. Siggs, T. Young, V. Vitart, A. Thiadens, J. Karjalainen, S. Uebe, R. Melles, K. S. Nair, R. Luben, Mark J. Simcoe, Nishani Amersinghe, A. Cree, Rene Hohn, A. Poplawski, L. J. Chen, S. Rong, T. Aung, E. Vithana, G. Tamiya, Yukihiro Shiga, Masayuki Yamamoto, T. Nakazawa, Hannah Currant, E. Birney, Xin Wang, A. Auton, Michelle K. Lupton, N. Martin, A. Ashaye, O. Olawoye, S. Williams, S. Akafo, M. Ramsay, Kazuki Hashimoto, Y. Kamatani, M. Akiyama, Y. Momozawa, P. Foster, P. Khaw, J. Morgan, N. Strouthidis, P. Kraft, J. Kang, C. Pang, F. Pasutto, P. Mitchell, A. Lotery, A. Palotie, C. V. van Duijn, J. Haines, C. Hammond, L. Pasquale, C. Klaver, M. Hauser, C. Khor, D. Mackey, M. Kubo, Ching-Yu Cheng, J. Craig, S. Macgregor, J. Wiggs   +78 more
semanticscholar   +1 more source

Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review

Scientific Reports, 2021
Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for ...
Nan Zhang, Jiaxing Wang, Ying Li, B. Jiang   +3 more
semanticscholar   +1 more source

Three‐year effectiveness and safety of the XEN gel stent as a solo procedure or in combination with phacoemulsification in open‐angle glaucoma: a multicentre study

Acta ophthalmologica, 2021
To assess the 3‐year effectiveness and safety of the XEN gel stent implanted ab interno in open‐angle glaucoma (OAG).
H. Reitsamer, Vanessa Vera, S. Ruben, L. Au, J. Vila-Arteaga, M. Teus, Markus Lenzhofer, A. Shirlaw, Zhanying Bai, M. Balaram, I. Stalmans   +10 more
semanticscholar   +1 more source

Racial and Ethnic Disparities in Primary Open-Angle Glaucoma Clinical Trials

JAMA Network Open, 2021
Key Points Question What is the prevalence of participants from racial/ethnic minority groups compared with White individuals in primary open-angle glaucoma (POAG) clinical trials? Findings In this meta-analysis of 33 428 POAG clinical trial participants,
Karen Allison, Deepkumar Patel, Leah Greene   +2 more
semanticscholar   +1 more source

Primary Open-Angle Glaucoma [PDF]

New England Journal of Medicine, 2009
Primary open-angle glaucoma (POAG), by far the most common form of glaucoma, currently afflicts more than 2 million Americans, more than half of whom probably don't know they have it. Asymptomatic in the early stages, it gradually and progressively reduces the visual field and leads to blindness if untreated.
Georgia Deretzi, Jannis Kountouras, Christos Zavos   +2 more
  +10 more sources

Biallelic CPAMD8 variants are a frequent cause of childhood and juvenile open-angle glaucoma [PDF]

, 2020
Purpose: Developmental abnormalities of the ocular anterior segment in some cases can lead to ocular hypertension and glaucoma. CPAMD8 is a gene of unknown function recently associated with ocular anterior segment dysgenesis, myopia, and ectopia lentis ...
Burdon, KP, Chappell, A, Craig, JE, Dubowsky, A, Elder, JE, Hewitt, AW, Javadiyan, S, Kearns, LS, Mackey, DA, Narita, A, Nicholl, J, Pater, J, Ruddle, JB, Siggs, OM, Smith, JEH, Souzeau, E, Staffieri, SE, Taranath, DA, Zhou, T   +18 more
core   +5 more sources

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Journal of Clinical Medicine, 2020
Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma.
A. Grzybowski, Mariusz Och, P. Kanclerz, C. Leffler, C. G. Moraes   +4 more
semanticscholar   +1 more source