Results 91 to 100 of about 1,102,129 (260)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

223Ra-dichloride therapy of bone metastasis: optimization of SPECT images for quantification

EJNMMI Research, 2019
Background 223Ra imaging is crucial to evaluate the successfulness of the therapy of bone metastasis of castration-resistant prostate cancer (CRPC).
Nadia Benabdallah, Michela Bernardini, Marta Bianciardi, Claire de Labriolle-Vaylet, Didier Franck, Aurélie Desbrée   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Robust wavebuoys for the marginal ice zone: Experiences from a large persistent array in the Beaufort Sea

Elementa: Science of the Anthropocene, 2017
An array of novel directional wavebuoys was designed and deployed into the Beaufort Sea ice cover in March 2014, as part of the Office of Naval Research 'Marginal Ice Zone' experiment. The buoys were designed to drift with the ice throughout the year and
Martin J. Doble, Jeremy P. Wilkinson, Lovro Valcic, Jeremy Robst, Andrew Tait, Mark Preston, Jean-Raymond Bidlot, Byongjun Hwang, Ted Maksym, Peter Wadhams   +9 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Beta Cephei stars in the ASAS-3 data. I. Long-term variations of periods and amplitudes

, 2007
We analysed V-filter ASAS-3 photometry of 41 known Beta Cephei-type stars. The ASAS-3 photometry was combined with the archival data, if available, to determine long-term stability of periods and amplitudes of excited modes. We detected amplitude changes
A. Pigulski, Aerts, Aerts, Baade, Balona, Balona, Balona, Balona, Balona, Bruntt, Cappa, Cuypers, De Mey, Deutschmann, Dziembowski, Dziembowski, Dziembowski, Engelbrecht, Feast, Feast, FitzGerald, Floquet, Freyhammer, Fullerton, G. Pojmański, Garrison, Handler, Handler, Handler, Herbst, Hill, Hill, Howarth, Howarth, Humphreys, Jerzykiewicz, Jerzykiewicz, Jerzykiewicz, Jerzykiewicz, Johansson, Kaltcheva, Kaltcheva, Kambe, Klare, Koen, Koen, Kołaczkowski, Kołaczkowski, Krzesinski, Kuntz, Lehner, Levato, Lodén, Lynn, MacConnell, Mathys, McSwain, Miglio, Moffat, Morgan, Penny, Penny, Peterson, Pigulski, Pigulski, Pigulski, Porter, Rivinius, Savonije, Schild, Schmidt-Kaler, Shobbrook, Shobbrook, Smolec, Stankov, Stefl, Sterken, Sterken, Townsend, Uytterhoeven, Uytterhoeven, van den Bergh, Vogt, Waelkens, Waelkens, Waelkens, Walborn, Walker, Walker, Walker, Wiegert, Yang, Yudin   +92 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Monte Carlo study of gating and selection in potassium channels

, 2011
The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles.
A. L. Hodgkin, A. M. J. VanDongen, B. Hille, Daniele Andreucci, Dario Bellaveglia, Emilio N. M. Cirillo, Silvia Marconi   +6 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source