Results 141 to 150 of about 156,514 (326)

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias? [PDF]

, 2014
INTRODUCTION: Two methods of non-invasive brain stimulation, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have demonstrable positive effects on cognition and can ameliorate neuropsychiatric symptoms such as ...
Elder, Greg, Taylor, John-Paul
core   +1 more source

A trial like ALIC4E: why design a platform, response-adaptive, open, randomised controlled trial of antivirals for influenza-like illness?

ERJ Open Research, 2018
ALIC4E is the first publicly funded, multicountry, pragmatic study determining whether antivirals should be routinely prescribed for influenza-like illness in primary care.
Christopher C. Butler, Samuel Coenen, Benjamin R. Saville, Johanna Cook, Alike van der Velden, Jane Homes, Menno de Jong, Paul Little, Herman Goossens, Philippe Beutels, Margareta Ieven, Nick Francis, Pieter Moons, Emily Bongard, Theo Verheij   +14 more
doaj   +1 more source

A Phase II Randomized, Double-Blind, Placebo-Controlled Safety and Efficacy Study of Lenalidomide in Lumbar Radicular Pain with a Long-Term Open-Label Extension Phase [PDF]

, 2016
Donald C. Manning, Joseph Gimbel, Robert T. Wertz, Richard Rauck, Alyse Cooper, Jerome B. Zeldis, D. Levinsky   +6 more
openalex   +1 more source

Temperature and Farm Labor in Nigeria

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We estimate the impact of temperature shocks on the composition of farm labor in rural Nigeria using a nationally representative household panel survey. Leveraging plausibly exogenous year‐to‐year variation in growing season temperatures, we find that warmer temperatures significantly alter farm labor composition, prompting a substantial shift
Andu Berha
wiley   +1 more source

Reductions in acute medication use and healthcare resource utilization in patients with chronic migraine: a secondary analysis of a phase 3, randomized, double-blind, placebo-controlled study of galcanezumab with open-label extension (REGAIN)

, 2022
Joshua Tobin, Shivang Joshi, Janet H. Ford, Russell Nichols, Shonda A. Foster, Dustin Ruff, Holland C. Detke, Sheena K. Aurora   +7 more
openalex   +1 more source

Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Adult Males

Anesthesiology, 2019
Background: Open label placebos with patient education are effective in reducing chronic pain, and recent studies on their effect on pain have established interest in this field.
T. Schneider, Julian Luethi, E. Mauermann, O. Bandschapp, W. Ruppen   +4 more
semanticscholar   +1 more source

Current Status of Multidisciplinary Treatment Strategies for Hepatocellular Carcinoma in the Era of Advanced Systemic Therapies

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT The therapeutic landscape of hepatocellular carcinoma (HCC) has been transformed by recent advancements in systemic therapies, particularly with the introduction of immune checkpoint inhibitors, expanding treatment options beyond conventional locoregional approaches.
Keiichi Akahoshi, Shun Kaneko, Shinji Tanaka, Minoru Tanabe, Daisuke Ban   +4 more
wiley   +1 more source

Migraine treatment in developmental age: guidelines update [PDF]

, 2010
There is a serious lack of controlled studies on the pharmacological treatment of primary migraine in the developmental age; there is, consequently, an urgent need for new, evidence-based approaches to this long-neglected field of research.
Alberto Spalice, Francesco Nicita, Laura Papetti, Maria Chiara Paolino, Maria Pia Villa, Paola Iannetti, Pasquale Parisi, Rosa Castaldo   +7 more
core   +4 more sources

Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations [PDF]

, 2019
Stefanie H. Meeuwis, Henriët van Middendorp, Antoinette I. M. van Laarhoven, Dieuwke S. Veldhuijzen, A.P.M. Lavrijsen, Andrea W.M. Evers   +5 more
openalex   +1 more source