Topiramate augmentation in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial [PDF]
, 2014 Background: This study aimed to assess the efficacy of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (OCD) as an adjunct to serotonin reuptake inhibitors (SRIs).
Afshar, Hamid. +3 more
core +2 more sources
Open label placebo: pill and needle
Integrative Medicine Research, 2020 Younbyoung Chae +2 more
openaire +3 more sources
Advanced Science, EarlyView.Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra +9 more
wiley +1 more source
Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension [PDF]
, 2011 Veronika Vakhapova +4 more
openalex +1 more source
Open-label placebo for insomnia (OPIN): study protocol for a cohort multiple randomised controlled trial [PDF]
, 2021 Ben Colagiuri +6 more
openalex +1 more source
A fixed-dose randomized controlled trial of olanzapine for psychosis in Parkinson disease [PDF]
, 2013 Background: Psychosis is a common and debilitating side effect of long-term dopaminergic treatment of Parkinson disease (PD). While clozapine is an effective treatment, the need for blood monitoring has limited its first-line use.
Black, Kevin J +4 more
core +3 more sources
Advanced Science, EarlyView.Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang +11 more
wiley +1 more source
Ocular safety of sildenafil citrate when administered chronically for pulmonary arterial hypertension: results from phase III, randomised, double masked, placebo controlled trial and open label extension [PDF]
, 2012 Barbara Wirostko +4 more
openalex +1 more source
Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One‐Year Results of a Double‐Blind, Placebo‐Controlled Study and Open‐Label Extension [PDF]
, 2021 Atul Deodhar +11 more
openalex +1 more source
Advanced Science, EarlyView.This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer +8 more
wiley +1 more source