Would You Take an Open-Label Placebo Pill or Give One to Your Child? Findings from a Cross-Sectional Survey [PDF]
Psychology Research and Behavior ManagementAnne Schienle, Arved Seibel Department of Clinical Psychology, University of Graz, Graz, AustriaCorrespondence: Anne Schienle, Email anne.schienle@uni-graz.atBackground: Open-label placebos (OLPs), honestly prescribed regarding their inert nature, have ...
Schienle A, Seibel A
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Talking placebo: a qualitative study of patients’ attitudes toward open-label placebo implementation into clinical practice [PDF]
Frontiers in PsychologyBackgroundFor more than a decade, studies have supported the efficacy and safety of placebos without deception—so-called open-label placebos (OLPs)—to harness placebo effects in primary care while aligning with key ethical principles.
Antje Frey Nascimento +12 more
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JAMA Netw OpenKey Points Question What are the clinical effects and brain mechanisms of open-label (honestly prescribed) placebos for chronic back pain? Findings In this randomized clinical trial of 101 adults with chronic back pain, an open-label subcutaneous placebo
Ashar YK +6 more
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Author Correction: Effects of open-label placebos in clinical trials: a systematic review and meta-analysis [PDF]
Scientific Reports, 2021 Melina von Wernsdorff +3 more
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Open label placebo to treat fatigue in people with multiple sclerosis: feasibility and preliminary effects [PDF]
Pilot and Feasibility StudiesBackground Fatigue is highly prevalent in adults with multiple sclerosis (MS) and current treatments offer limited benefit. It has been speculated that placebos only have an effect when they are administered with deception and concealment, which is ...
Navneet Kaur Baidwan +8 more
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European Annals of Allergy and Clinical Immunology, 2017 Tadech Boonpiyathad +1 more
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The health economic potential of harnessing placebos in treatment of ADHD
European Psychiatry, 2021 Introduction Placebo research investigated the underlying mechanisms of placebo effects, but they are rarely used to optimize treatments. Ethical and legal concerns have been raised, but research demonstrated that placebo mechanisms can be used without
J. Hamberger +3 more
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A comparison of open-label and deceptive placebo analgesia in a healthy sample [PDF]
Journal of Psychosomatic Research, 2021 A small number of studies have supported the efficacy of open-label placebos (OLPs) in reducing pain. However, research comparing the effectiveness of OLPs with deceptive placebos (DPs) is limited, and the relative impact on pain tolerance versus intensity are not yet understood.
Chris Retzler +2 more
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BMC Medicine, 2023 Background Overtreatment poses a challenge to healthcare systems due to harmful consequences of avoidable side-effects and costs. This study presents the first account for examining the feasibility of placebo use for reducing overtreatment in primary ...
E. M. Krockow +4 more
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Can an Open-Label Placebo Be as Effective as a Deceptive Placebo? Methodological Considerations of a Study Protocol [PDF]
Medicines, 2020 Background: Placebo has been studied for many years and is ever-present in healthcare. In clinical practice, its use is limited by ethical issues raised by the deception entailed by its administration. Objective: To investigate whether, when given detailed information about pain and underlying placebo mechanisms, subjects will have a response similar ...
Leo Druart +6 more
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