Results 41 to 50 of about 3,973 (220)
Scientific Reports, 2022 Placebos are known to yield significant effects in many conditions. We examined deceptive and open-label placebo effects on guilt, which is important for self-regulation and a symptom of mental disorders.
Dilan Sezer, Cosima Locher, Jens Gaab
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PLoS ONE, 2022 Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo ...
Yiqi Pan +3 more
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Frontiers in Psychology, 2021 In recent years, the postulation that deception is necessary for placebos to have an effect on pain relief or increased well-being has come into question. Latest studies have shown that an openly administered mock drug works just as well as a deceptively
Marco Rathschlag +3 more
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Placebos in the era of open‐label trials: An update for clinicians [PDF]
European Journal of Clinical Investigation, 2018 AbstractPlacebos have been used extensively by vast numbers of physicians, in a majority of clinical trials. Placebo effects involve behavioural, psychological and genetic factors and have been subject to ethical controversies stemming from the use of deception in treating patients.
Iftach Sagy +3 more
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Can Observational Learning Reinforce Open-label Placebo Hypoalgesia?
Pain, 2023 Previous research has indicated that an open-label placebo can reduce pain in both healthy participants and chronic pain patients. As nondeceptive placebos seem to be an effective and more ethical alternative to deceptive placebos, optimizing this kind of treatment is essential.
Justyna Brączyk, Przemysław Bąbel
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Neural underpinnings of open-label placebo effects in emotional distress
Neuropsychopharmacology, 2022 AbstractWhile placebo effects are well-known, research in the last decade revealed intriguing effects that placebos may have beneficial effects even when given without deception. At first glance, this seems paradoxical, but several studies have reported improvements in pain, depression, or anxiety.
Michael Schaefer +4 more
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The role of positive information provision in open‐label placebo effects
Applied Psychology: Health and Well-Being, 2023 Abstract Open label placebos (OLPs) appear generally efficacious among clinical samples, but the empirical evidence regarding their use in non‐clinical and sub‐clinical samples, as well as when administered independent of a convincing rationale, is mixed. Healthy participants ( N
Kirsten Barnes +4 more
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Placebos without deception: a randomized controlled trial in irritable bowel syndrome. [PDF]
PLoS ONE, 2010 Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception.
Ted J Kaptchuk +9 more
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Can an Open-Label Placebo Be as Effective as a Deceptive Placebo? Methodological Considerations of a Study Protocol [PDF]
Medicines, 2020 Background: Placebo has been studied for many years and is ever-present in healthcare. In clinical practice, its use is limited by ethical issues raised by the deception entailed by its administration. Objective: To investigate whether, when given detailed information about pain and underlying placebo mechanisms, subjects will have a response similar ...
Leo Druart +6 more
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Why psychotherapy is an open-label placebo and open-label placebos are psychotherapy
, 2023 Abstract In recent years, placebos have undergone a rapid development from methodological chaff to therapeutic wheat. Hereby, the role of placebos as a deceptive control in clinical trials, as well as negative denomination for anything murky, changed to an innovative promise, an effective as well as ethical treatment.
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