Open-label Placebos for Wound Healing: A Randomized Controlled Trial [PDF]
Annals of Behavioral Medicine, 2018 Open-label placebos are a novel treatment option, in which participants take placebos with full knowledge that they do not contain active medicine. Open-label placebo treatments have been shown to result in patient-reported symptom improvements, but they have not been tested on objectively measurable physiological outcomes such as wound healing.The ...
Paul Jarrett +2 more
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Open-Label Placebo Treatment for Acute Postoperative Pain (OLP-POP Study): Study Protocol of a Randomized Controlled Trial [PDF]
Frontiers in Medicine, 2021 Introduction: Open-label placebos have been proposed as way of using long recognized analgesic placebo effects in an ethical manner. Recent evidence shows efficacy of open-label placebos for clinical conditions, but there is need for more research on ...
Dilan Sezer +10 more
doaj +2 more sources
Effects of open-label placebos in clinical trials: a systematic review and meta-analysis [PDF]
Scientific Reports, 2021 Open-label placebos (OLPs) are placebos without deception in the sense that patients know that they are receiving a placebo. The objective of our study is to systematically review and analyze the effect of OLPs in comparison to no treatment in clinical ...
Melina von Wernsdorff +3 more
doaj +2 more sources
Open-label placebos—a systematic review and meta-analysis of experimental studies with non-clinical samples [PDF]
Scientific Reports, 2023 The use of open-label placebos (OLPs) has shown to be effective in clinical trials. We conducted a systematic review and meta-analysis to examine whether OLPs are effective in experimental studies with non-clinical populations. We searched five databases
Lukas Spille +4 more
doaj +2 more sources
Open-label placebos reduce hair cortisol concentrations and psychological distress - a randomized controlled trial [PDF]
Scientific ReportsThe exposure to stressful events, such as demanding university exams, is associated with psychological distress and elevated physiological stress responses, which may impair performance.
Carolin Liedtke +2 more
doaj +2 more sources
JAMA Netw OpenImportancePlacebo effects contribute substantially to the therapeutic success of many treatments, particularly in pain-related conditions. Open-label placebos (OLPs) offer an ethically acceptable approach to harness this potential without deception.ObjectiveTo evaluate the efficacy of a 3-month OLP regimen in reducing headache and migraine days and ...
Kleine-Borgmann J +6 more
europepmc +5 more sources
Effects of Open-Label Placebos on Visual Food Cue Reactivity in Children and Adolescents [PDF]
ChildrenBackground: A high level of food cue reactivity (FCR) is a risk factor for overeating and weight gain. This randomized trial investigated whether open-label placebos (OLPs: placebos honestly administered) can reduce FCR (reported appetite) in children ...
Anne Schienle +4 more
doaj +2 more sources
Effects of open-label placebos and self-monitoring in skin-picking disorder: a randomized crossover trial [PDF]
Frontiers in PsychiatryBackgroundSymptom reduction in skin-picking disorder (SPD) has previously been demonstrated using deceptive placebo treatments. However, to date, no study has investigated the effects of open-label placebos (OLPs) in this context.MethodFifty-two ...
Anne Schienle +2 more
doaj +2 more sources
Open-label placebos for menopausal hot flushes: a randomized controlled trial. [PDF]
Sci Rep, 2020 AbstractThis study investigated the efficacy of an open-label placebo (OLP) treatment for menopausal hot flushes. Women with at least five moderate or severe hot flushes per day were allocated to receive four weeks of OLP for twice a day or no-treatment. Intention-to-treat analyses included n = 100 women.
Pan Y +5 more
europepmc +4 more sources
Open-Label Placebos Are Deceptive and Should Not Be Used in Clinical Practice [PDF]
Voices in BioethicsPhoto ID 198462485 © Nastassia Samal | Dreamstime.com Open-label placebo (OLP) research has proliferated rapidly in the past two decades, with studies claiming benefit for irritable bowel syndrome, chronic pain, ADHD, allergic rhinitis, and other ...
Steven Tresker, Pekka Louhiala
doaj +3 more sources