Open-label placebos as adjunctive therapy for patients with depression [PDF]
Contemporary Clinical Trials Communications, 2022 Background: Placebos prescribed as ‘regular’ medication can reduce symptoms of depression. However, using a placebo without patients' informed consent presents ethical issues.
Anne Schienle, Nina Jurinec
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Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses [PDF]
Brain Sciences, 2021 Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative ...
Michael Schaefer +2 more
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Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos [PDF]
Scientific ReportsRecent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be cleared. For example,
Michael Schaefer +2 more
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Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
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Open-label placebos reduce weight in obesity: a randomized controlled trial [PDF]
Scientific ReportsObesity is a major public health problem worldwide. Different approaches are known to face this problem, for example, dieting, surgery, or drug interventions. It has also been shown that placebos may help to reduce weight and hunger feelings, but the use
Michael Schaefer +2 more
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Open-label placebos enhance test performance and reduce anxiety in learner drivers: a randomized controlled trial [PDF]
Scientific ReportsPassing the driving school test can be very challenging, especially in big cities, where up to 52% of all students fail this test. Consequently, many learner drivers experience stress and anxiety.
Michael Schaefer, Sören Enge
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Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms [PDF]
Scientific Reports, 2023 Placebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way to harness placebo effects ethically.
Sarah Buergler +6 more
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Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations [PDF]
Bioethics, 2016 AbstractThe doctor‐patient relationship is built on an implicit covenant of trust, yet it was not until the post‐World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses ...
Charlotte Blease +2 more
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A qualitative study of imaginary pills and open-label placebos in test anxiety [PDF]
PLoS ONE, 2023 Background The efficacy of open-label placebos (OLPs) has been increasingly demonstrated and their use holds promise for applications compatible with basic ethical principles.
Sarah Buergler +9 more
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Can open label placebos improve pain and gluten tolerance via open label placebos in fibromyalgia patients? A study protocol for a randomised clinical trial in an outpatient centre [PDF]
BMJ Open, 2023 Introduction Fibromyalgia syndrome (FMS) is defined as a medical condition with chronic widespread musculoskeletal pain accompanied by mood disorders, fatigue and sleep disturbances. Treatment of this condition can often be challenging.
Margitta Worm +3 more
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