Results 31 to 40 of about 2,099 (258)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Stability Characteristics of a Model Trim Adjustment System for Open Loop Active Control of Thermoacoustic Instability

Journal of Aerospace Technology and Management, 2019
Thermoacoustic instability in liquid rocket engines can have potentially catastrophic consequences. Active control based on feedback promises improved stability margin over a wider range of operating conditions than passive control.
Varghese M Thannickal, T John Tharakan, Satyanarayanan R Chakravarthy   +2 more
doaj   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experimental Investigation of Mode Localization’s Bifurcation Topology Transfer in Electrostatically Coupled Tuning Fork Resonators

Sensors
Bifurcation topology transfer phenomena in the presence of mode localization are investigated using double-ended fixed electrostatically coupled tuning fork resonators.
Ming Lyu, Xiang Zhi, Na Yan, Rongjian Sun   +3 more
doaj   +1 more source

Cylindrical Shell Vibration Gyroscope Excited and Detected by High-Temperature-Sintered Piezoelectric Ceramic Electrodes

Sensors, 2020
A cylindrical shell piezoelectric vibration gyroscope is a kind of Coriolis vibration gyroscope. Its core components are the cylindrical quartz resonator (CQR) and the piezoelectric ceramic electrodes (PCEs).
Tianliang Qu, Guanqing Zhou, Xiaoming Xue, Junhua Teng   +3 more
doaj   +1 more source

BPFs with oct-resonance and -transmission-zero realized by coupling optimization on open-loop resonator

Journal of Electromagnetic Waves and Applications, 2021
This paper presents a series of novel designs for dual-band bandpass filters (BPFs) with excellent in-band and out-band filtering performances. By imbedding the spiral-line resonator into the coupling open-loop structures and adjusting the symmetrical structure, the second-order quad-mode BPFs are designed and then the fourth-order oct-mode dual-band ...
Xiao Wang, Jun-Ge Liang, He Jing, Jia-Kang Wu, Nam-Young Kim, Xiao-Feng Gu   +5 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Balanced-to-Balanced Microstrip Diplexer Based on Magnetically Coupled Resonators

IEEE Access, 2018
Two balanced-to-balanced planar diplexers based on magnetically coupled microstrip resonators are proposed in this paper. For the first prototype, each channel/differential-output is composed of a second order single-band balanced bandpass filter based ...
Armando Fernandez-Prieto, Aintzane Lujambio, Jesus Martel, Francisco Medina, Ferran Martin, Rafael R. Boix   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Hexagonal open loop resonators employing frequency shift coding for Chipless RFID tag applications [PDF]

International Journal of Electronics and Telecommunications
A novel, high surface encoding capacity compact planar multiresonator tailored for Chipless RFID tag applications is discussed in this article. The tag consists of three hexagonal open loop resonators that are etched on the ground plane of a 50Ω ...
Harikrishnan A I, Mary Neebha, Sumi M
doaj   +1 more source