Results 131 to 140 of about 99,963 (219)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

Never Mind the Bollards: Exploring the Role of GCHQ, MI5, and the National Technical Authorities in UK Security Markets

open access: yesThe Howard Journal of Crime and Justice, EarlyView.
ABSTRACT The cultures and governance of security markets in the United Kingdom are often characterised through a paradoxical narrative of simultaneous state retreat and progressive advance. In the face of repeated recent high‐profile security failures, and global changes in material political economy, we argue that UK security governance is adapting to
Ben Collier, Jamie Buchan
wiley   +1 more source

More Than Words: The Multimodal Practice of Repetition in English as a Lingua Franca Interactions

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT This study investigates the use of repetition as an interactional resource in video‐recorded English as a Lingua Franca (ELF) interactions, focusing on partial repeats produced in responses to wh‐questions. By adopting a multimodal conversation analytic approach, the analysis demonstrates that repetition in this context may either index the ...
Yujong Park
wiley   +1 more source

Exact and metaheuristic approaches to minimizing makespan in parallel machine scheduling with conflicting jobs

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract We address the scheduling conflicting jobs on parallel identical machines problem with makespan minimization, a classical and computationally challenging variant of parallel machine scheduling. We develop and evaluate three distinct solution methodologies: a novel constraint programming (CP) formulation, and two metaheuristics: a multi ...
Roberto Maria Rosati   +3 more
wiley   +1 more source

Park‐and‐multi‐loop with autonomous delivery robots in last‐mile logistics

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract This paper deals with the park‐and‐multi‐loop routing problem, in the context of last‐mile logistics, in which a fleet of traditional vehicles equipped with several autonomous delivery robots leaves from a depot to service a set of customer requests.
Tommaso Adamo   +4 more
wiley   +1 more source

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