Results 61 to 70 of about 174,498 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Key Technology and Intelligent Management and Control Concept of Intelligent Construction of Open-pit Coal Mine

open access: yesMeikuang Anquan, 2020
This paper first analyzes the existing problems of open-pit coal mine from the perspective of industry background, policy guidance, management and control concept, expounds the necessity of establishing intelligent mine, studies the definition, overall ...
HE Shuai, WANG Haiyang, ZHAO Li
doaj   +1 more source

Data mining for mine-mill ore grade reconciliation at Erdenet Mining Corporation [PDF]

open access: yes, 2016
Master's Project (M.S.) University of Alaska Fairbanks, 2016This project investigates the relationship between the mined ore and the produced copper at the Erdenet Mining Corporation (EMC) surface copper mine in Mongolia.
Sarantsatsral, Narmandakh
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Unravelling the relative contributions of climate change and ground disturbance to subsurface temperature perturbations: Case studies from Tyneside, UK [PDF]

open access: yes, 2016
When assessing subsurface urban heat islands (UHIs) it is important to distinguish between localized effects of land-use change and the impacts of global climate change. However, few investigations have successfully unraveled the two influences.
Westaway, Rob, Younger, Paul L.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

A case of compatibility between quarrying of ornamental granite and forest exploitation [PDF]

open access: yes, 2012
A particular development is proposed to mine some good quality out crops of granite found in a forest exploitation of eucalypts. The exploitation has been designed with a quarrying method, in which small open cast pits are opened and quarried ...
Alfonso Rodríguez Dono   +3 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

The Fontao’s mine [PDF]

open access: yes, 2002
[Abstract] The Fontao Mine (Vila de Cruces) was exploited from 1934 to 1973, having a little period without activity (1963-1968) in wich underground mining was changed to open pit. L a t e r , the mine has remained closed.
Orche, E.
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

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