Results 201 to 210 of about 2,140,549 (295)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety. [PDF]

Br J Clin Pharmacol
Burckart GJ, Abdel-Rahman SM, Abulwerdi G, Racz R, Samuels S, Green DJ, Yao LP.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Practical Method for Monitoring Patient Safety Culture: Applying Net Promoter Score and Lot Quality Assurance Sampling. [PDF]

J Eval Clin Pract
Lopez-Picazo JJ, Vidal-Abarca I, Marín-Martinez JM.   +2 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

A study protocol for a baseline community-based cross-sectional study to investigate malaria and dengue transmission dynamics in a development area of new capital city, Indonesia. [PDF]

Wellcome Open Res
Pradana A, Oktaviani M, Prameswari H, Supriyanto D, Waluyo P, Ndoen E, Rosadi D, Lubis I, Suwarti S, Subekti D, Kusumaningrum T, Carroll M, Djaafara B, de Alwis R, Mishra S, Drakeley C, Leder K, Lechner A, Fornace K, Elyazar I, Surendra H.   +20 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Decolonizing global health in an age of fragmentation: reimagining equity for universal health coverage. [PDF]

Health Policy Plan
Afriyie EK, Mbwoge RN, Koray MH.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Leveraging global tools for adolescent and youth health planning and programming: process and lessons learnt from Madagascar. [PDF]

Glob Health Action
Ngabonzima A, Keogh SC, Guthold R, Lydia Yasmine L, Bisoborwa GK, Andrianasolo S, Siga Diane Niane E, Ye M, Rajoelina MT, Rakotomahefa Fetrarivo N, Musango L.   +10 more
europepmc   +1 more source