Results 241 to 250 of about 2,099,286 (284)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Letter to the editor re: fatal intracranial haemorrhage after belzutifan initiation. [PDF]

ESMO Open
Broekman KE, van Gils MPMQ, Baron A, Poplavska E, Mol PGM.   +4 more
europepmc   +1 more source

Local lighting control in open-plan offices: acceptable or distracting?

, 2017
De Bakker, Christel, Aarts, Mariëlle, Kort, Helianthe, Rosemann, Alexander   +3 more
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Exploring the Feasibility of Paper-Based Substrates for User-Friendly Electrochemiluminescent Sensors. [PDF]

Anal Chem
Kalligosfyri PM, Scognamiglio L, Sossich E, Cheng N, Polo F, Cinti S.   +5 more
europepmc   +1 more source

Transforming caregivers into partners: advancing WHO patient safety goals in Singapore acute hospital. [PDF]

BMJ Open Qual
Teo KY, Yuan LX, Kan SH, Ho AL, Ng GNJ.
europepmc   +1 more source

Implementation of mental health policies and plans across the WHO European region: Barriers and facilitators. [PDF]

Glob Ment Health (Camb)
Guerrero Z, Kågström A, Tomaskova H, Aliev A, Yon Y, Lazeri L, Redlich C, Winkler P.   +7 more
europepmc   +1 more source

Two Nations, One Front: Indonesia and Papua New Guinea forge a One-Island approach to fight persistent malaria on New Guinea. [PDF]

Nat Commun
Prameswari HD, Kisomb J, Mapira P, Keven JB, Susanto H, Isa R, Supriyanto D, Garjito TA, Syafruddin D, Ndoen E, Iswahyudi, Firmansyah, Permana F, Chin N, Lobo NF, Walker ED, Laihad FJ, Das S, Hawley WA, Elyazar IR.   +19 more
europepmc   +1 more source