Results 151 to 160 of about 16,453,163 (304)

The path to adoption of open source AI for drug discovery in Africa

Artificial Intelligence in the Life Sciences
Gemma Turon, Miquel Duran-Frigola
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Flüssiger Code - Open Source Software in der Medienkunst

, 2007
Im Rahmen dieses Artikels wird ein Überblick über die Anwendung von Open Source Software im Bereich der Kunst - hier vor allem den verschiedenen Spielarten der Medienkunst - gegeben.
Pichlmair, Martin
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Editorial: Alleviating age-related disease burden

Frontiers in Aging
Matthew Halma, Sidra Hassaan, Jack A. Tuszynski, Jack A. Tuszynski   +3 more
doaj   +1 more source

FilmQADose: Open-source software for radiochromic film dosimetry. [PDF]

J Appl Clin Med Phys
Herrera-Alba E, Contreras-Quiroz C, Sandoval-Navia J, Vásquez J, Ávila C.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

PAPRECA: a parallel hybrid off-lattice kinetic Monte Carlo/molecular dynamics simulator

Kinetic Monte Carlo (kMC) is an atomistic and stochastic simulation technique that captures the temporal evolution of various systems in materials science, chemistry, physics, biology, and engineering.
Ntioudis, Stavros, Dini, Daniele, Turner, C Heath, Ewen, James P   +3 more
core   +1 more source

Machine Learning Approaches Identify Chemical Features for Stage-Specific Antimalarial Compounds

ACS Omega, 2023
Ashleigh van Heerden, Gemma Turon, Miquel Duran-Frigola, Nelishia Pillay, Lyn-Marié Birkholtz   +4 more
doaj   +1 more source

Open-Source Multinuclear Low-Field Preclinical MRI Scanner. [PDF]

NMR Biomed
Rodriguez GG, Korchak S, von Petersdorff-Campen C, Sucre O, Felger J, Mei R, Glöggler S.   +6 more
europepmc   +1 more source