Results 131 to 140 of about 16,453,163 (304)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Copyright versus Patents: the Open Source Software Legal Battle [PDF]
Open Source Software is often viewed as an anti-intellectual property regime. By contrast, we argue how IP law is at the heart of open source model since licenses that organize the innovation and business relationships between developers, distributors ...
Yann Ménière, François Lévêque
core
Institutional Repositories, Open Source Options, and Libraries [PDF]
, 2008 This paper examines the purposes of institutional digital repositories and the development options that are available via open source software. Preservation of an institution's digital output is valuable to the submitting authors and the institution ...
Amaral, Megan E.
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Eight Things you should Know about Open Source Integrated Library Systems. [PDF]
, 2009 Open source library management systems are free alternative to costly commercial library systems. It helps to automate library functions and give a tremendous savings on library automation expenses.
Abraham, Thomas, Vimal Kumar, V.
core
Perceptions and Uptake of Open Source in Swedish Organisations
, 2006 There are many different ways in which Open Source ideas can be adopted by business, and influence the way in which companies do business. A number of different surveys have been conducted in different countries with the purpose of understanding the ...
Lings, Brian, +5 more
core +1 more source
Guan'gai paishui xuebao【Objective】Accurate estimation of crop evapotranspiration (ETc) is essential for improving irrigation and water resource management. This study aimed to reduce the uncertainty in ETc estimation for winter wheat in the region of Nanjing and improve the ...
LU Lifang +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source