Results 121 to 130 of about 16,453,163 (304)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
A Robust Open Source Exchange for Open Source Software Development [PDF]
, 2006 This paper addresses the development of mechanisms for the creation of OSSD exchanges that could be used by developers across any geographical range, as long as all the developers can interact via some open network infrastructure such as the Internet. The structure of these exchanges can range from public repositories such as Sourceforge.net to intra ...
openaire +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Nature CommunicationsAfrica’s vast genetic diversity poses challenges for optimising drug treatments in the continent, which is exacerbated by the fact that drug discovery and development efforts have historically been performed outside Africa.
Gemma Turon +5 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Why open source software can succeed [PDF]
The paper discusses three key economic problems raised by the emergence and diffusion of Open source software: motivation, coordination, and diffusion under a dominant standard.
Cristina Rossi, Andrea Bonaccorsi
core
International Journal of Advanced Corporate Learning (iJAC), 2015 Here’s the Top 5 Security and Open Source Questions You Should Ask Your LMS ...
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Geocomputation and open source software: components and software stacks. [PDF]
Geocomputation, with its necessary focus on software development and methods innovation, has enjoyed a close relationship with free and open source software communities. These extend from communities providing the numerical infrastructure for computation,
Bivand, Roger
core
The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury
Advances in VirologyInjury from spike protein, whether induced by COVID-19 infection or vaccination, constitutes a significant health concern for numerous individuals. Considerable heterogeneity exists in individual responses to both COVID-19 infection and vaccination ...
Matthew Halma +5 more
doaj +1 more source