Results 121 to 130 of about 3,363,098 (286)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

OpenCSP: Collaborative Code and Data For CSP

SolarPACES Conference Proceedings
We are announcing OpenCSP, an open-source platform including source code, applications, and data to enable collaborative development for the CSP community worldwide, supporting industry, research, and education.
Randy Brost, Benjamin Bean, Felicia Brimigion, Margaret Gordon, Evan Harvey, Madeline Hwang, Tristan Larkin, Miranda Mundt, Nicholas Phelps, Braden Smith, Carly Tanaka-Lubensky   +10 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The Adoption of Open-Source software’s in Libraries in Digital Era

Journal of Information Management and Practices
This study aims to explore the adoption of Open-Source Software’s (OSS) in the academic libraries of Pakistan. It also focuses on the challenges encountered during the application and management of these software’s in both public and private sectors ...
Dr. Shahzad Ahmad, Muhammad Ibrahim, Dr. Sajjad Ahmad, Abid Hussain   +3 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Formal Assessment of Agreement and Similarity between an Open-Source and a Reference Industrial Device with an Application to a Low-Cost pH Logger

Sensors
Open-source devices are nowadays used in a vast number of research fields like medicine, education, agriculture, and sports, among others. In this work, an open-source, portable, low-cost pH logger, appropriate for in situ measurements, was designed and ...
Evmorfia P. Bataka, Persefoni Maletsika, Christos T. Nakas   +2 more
doaj   +1 more source

Modularity in action.GNU/Linux and free/Open source sotfware development model unleashed. [PDF]

Organizational and managerial theories of modularity applied to the design and production of complex artifacts are used to interpret the rise and success of Free/Open Source Software methodologies and practices in software engineeringmodularity; software
Alessandro Narduzzo, Alessandro Rossi
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

INFO2009 Group 1 -- Open Source Software Licensing Infographic [PDF]

An infographic for open source software licensing. This resource can serve as a simple introduction to open source software licensing, and as a reference for future ...
Kirkham, Christopher, Lynn, Alistair, May, Daniel, Puia, Alexandru   +3 more
core