Results 41 to 50 of about 1,342,549 (257)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

How Open Source Software Succeeds? A Review of Research on Success of Open Source Software

International Journal of Information and Communication Technology Research, 2014
Different aspects of Open Source Software (OSS) have been subject of many research in last decades. Among them many researchers have tried to adopt the pervasive literature of information systems success with this special kind of system development and ...
Alireza Amrollahi, Mohammad Khansari, Amir Manian   +2 more
doaj  

How Open Source Has Changed the Software Industry: Perspectives from Open Source Entrepreneurs [PDF]

Technology Innovation Management Review, 2012
The emergence of F/LOSS (free/libre open source software) has triggered several changes in the software industry. F/LOSS has been cited as an archetypal form of open innovation; it consists of the convergence and collaboration of like-minded parties.
Risto Rajala, Juho Lindman
doaj  

The Free Software Alternative: Freeware, Open Source Software, and Libraries

Information Technology and Libraries, 2014
: This paper will introduce the reader to the world of freeware and open source software. Following a brief introduction, the author presents an overview of these types of software.
James Edward Corbly
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Data Mining Techniques for Software Quality Prediction in Open Source Software [PDF]

EPJ Web of Conferences, 2019
Software quality monitoring and analysis are among the most productive topics in software engineering research. Their results may be effectively employed by engineers during software development life cycle.
Canaparo Marco, Ronchieri Elisabetta
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Analisa Tingkat Usability Software Open Source ICA-AtoM

Khazanah: Jurnal Pengembangan Kearsipan, 2017
Penelitian ini membahas dan mengkaji mengenai seberapa tingkat usability salah satu software bidang arsip digital dengan berbasis opensource yaitu ICA-AtoM. Latar belakang penulisan adalah dengan perkembangan teknologi informasi yang sudah menjadi bagian
Ach. Nizam Rifqi
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source