Results 81 to 90 of about 1,490,571 (305)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Open Source Software, Competition and Potential Entry [PDF]
We analyze a model with two software firms, quality improving coding expenditures and potential competition. The firms can publish parts of their software as open source.
Thorsten Wichmann, Pio Baake
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Open Source Software: From Open Science to New Marketing Models [PDF]
-Open source Software; Intellectual Property; Licensing; Business Model.
Paola Giuri +2 more
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The LaTeX project: A case study of open-source software [PDF]
This is a case study of TeX, a typesetting software that was developed by Donald E. Knuth in the late 70's. Released with an open source license, it has become a reference in scientific publishing. TeX is now used to typeset and publish much of the world'
Alexandre Gaudeul
core +2 more sources
Open Source Library Management Softwares [PDF]
, 2013 Open source software are those which permit execution, copy, read, distribution and improvement of the software without any restrictions. Library Management Software (LMS), is an enterprise resource planning system for a library, used to track items ...
Randhawa, Sukhwinder
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
How open is open source: Software and beyond [PDF]
Traditionally the protection of intellectual property is regarded as a precondition for value capture. The rise of open source (OS) software and OS tangible products, so-called open design, has challenged this understanding. Openness is often regarded as
Raasch, Christina +2 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Some Policy Issues on Open Source and Proprietary Software [PDF]
Software industry is a fast growing sector of the economy which is undergoing significant changes both for the presence of the open source mode of production and for the challenges of globalization and convergence with other industries.
Graziella Marzi
core