Results 81 to 90 of about 378,967 (294)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Memoirs of the Queensland Museum. [PDF]

, 1988
v.35:pt.2 ...
Hamlyn-Harris, Ronald, Hamlyn-Harris, Ronald, 1874-, Queensland Museum., Queensland Museum.   +3 more
core   +5 more sources

Synopsis of Acanthocerini (Hemiptera, Coreidae) from Argentina [PDF]

, 2013
Eight genera and 13 species of the tribe Acanthocerini are recorded in Argentina, i.e., Athaumastus haematicus (Stål), Athaumastus macer Brailovsky, Athaumastus subcarinatus (Stål), Athaumastus subterlineatus Bergroth, Beutelspacoris sanchezi Brailovsky,
Amyot, Bachmann, Berg, Berg, Berg, Bergroth, Blöte, Bosq, Bosq, Brailovsky, Brailovsky, Brailovsky, Brailovsky, Burmeister, Casini, Coscarón, Coscarón, Fabricius, Fabricius, Hayward, Hayward, Henry, José Pall, Kirkaldy, Kormilev, Lethierry, María del Carmen Coscarón, Mayr, Mayr, Mitchell, O’Shea, O’Shea, Packauskas, Packauskas, Pennington, Pennington, Quintanilla, Quintanilla, Quintanilla, Rizzo, Schaefer, Schaefer, Schuh, Signoret, Stål, Stål, Stål, Stål, Viana, Viana   +49 more
core   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A new species of Stenorrhachus McLachlan from Chile (Neuroptera: Nemopteridae) with biological notes [PDF]

, 2012
A new species of Stenorrhachus (McLachlan), S. chilensis (Neuroptera: Nemopteridae), is described from Chile with biological observations of Stenorrhachus walkeri (McLachlan). A key to the two species is provided as well as diagnoses of the adults and of
Miller, Robert B., Stange, Lionel A.
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Open abdomen critical care management principles: resuscitation, fluid balance, nutrition, and ventilator management

Trauma Surgery & Acute Care Open, 2017
The term “open abdomen” refers to a surgically created defect in the abdominal wall that exposes abdominal viscera. Leaving an abdominal cavity temporarily open has been well described for several indications, including damage control surgery and ...
Ram Nirula, Elizabeth Chabot
doaj   +1 more source

The open abdomen in trauma and non-trauma patients : WSES guidelines [PDF]

, 2018
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure ...
Abu-Zidan, Fikri M., Agnoletti, Vanni, Ansaloni, Luca, Arvieux, Catherine, Bala, Miklosh, Balogh, Zsolt J., Biffl, Walter, Bing, Camilla, Boffard, Ken, Catena, Fausto, Ceresoli, Marco, Chiara, Osvaldo, Chirica, Mircea, Cimbanassi, Stefania, Coccolini, Federico, Coimbra, Raul, DeAngelis, Nicola, Demetrashvili, Zaza, Ferrada, Paula, Fraga, Gustavo Pereira, Fugazzola, Paola, Galante, Joseph, Gamberini, Emiliano, Gomes, Carlos Augusto, Handolin, Lauri, Hecker, Andreas, Hernandez, Juan Alberto Martinez, Horer, Tal, Inaba, Kenji, Ivatury, Rao, Kashuk, Jeffry L., Khokha, Vladimir, Kike, Kaoru, Kirkpatrick, Andrew W., Kluger, Yoram, Kuo-Ching, Yuan, Larrea, Martha, Latifi, Rifat, Leppaniemi, Ari, Lin, Heng-Fu, Maier, Ron, Malbrain, Manu, Martzi, Ingo, Masiakos, Peter, Mefire, Alain Chichom, Melotti, Rita Maria, Montori, Giulia, Montravers, Philippe, Moore, Ernest E., Moya, Marc De, Naidoo, Noel, Napolitano, Lena, Ordoñez, Carlos A., Parry, Neil, Peitzman, Andrew, Pereira, Bruno M., Razek, Tarek, Reva, Viktor, Rizoli, Sandro, Roberts, Derek, Sakakushev, Boris, Salvetti, Francesco, Sartelli, Massimo, Saverio, Salomone Di, Scalea, Thomas, Simone, Belinda De, Soreide, Kjetil, Sugrue, Michael, Tolonen, Matti, Tomasoni, Matteo, Valetti, Tino M., Velmahos, George, Wani, Imtiaz, Weber, Dieter   +73 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source