Results 91 to 100 of about 96,836 (298)

Planning of public green open spaces to foster social interaction

, 2021
Urban areas are magnets for most of the people who look for job opportunities,technology, resources and proper facilities. In this process of urban development, the human scale is ignored; also, the social structure is disappeared.
Gode, Neetu Sanjay
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Surakarta’s Green Open Spaces: An Exploration of Their Biodiversity

IOP Conference Series: Earth and Environmental Science
Abstract Surakarta, also known as Solo, is strategically located to serve as a center of national activities. It is a key region of Central Java Province and forms part of the Joglosemar (Yogyakarta-Solo-Semarang) economic triangle. These factors have led to changes in land use for infrastructure development. As a
Okid Parama Astirin, Widya Mega Rahmawati, Puguh Karyanto, Nugroho Andi Purnomo, Hadi Wiwit Hendro Cahyono, Edy Suparmanto, Kristiana Hariyanti   +6 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Overlooked potentials of open spaces – new types and categories of urban landscapes [PDF]

Urbani Izziv, 2001
Cities possess numerous overlooked and under-utilised potential spaces for organising green surfaces and open urban spaces. They are defined by their position in the city, adequate contents nearby that could attract visitors and actual availability of ...
Ina Šuklje Erjavec
doaj  

Urban sustainability indicators and open green spaces

, 2023
Sustainability is a key concept used in many fields today. The concept, which takes its place in the urban planning literature, offers solutions against the negative effects of urbanization and rapid industrialization on societies and the environment.
Demiroğlu, Demet, Karadağ, Aybike Ayfer, Gül, Atila, Demirel, Öner, Seydoşoğlu, Seyithan, Zucaro, Floriana   +5 more
openaire   +1 more source

Landscape Fragmentation and Accessibility of Green Spaces

, 2019
To improve the positive effects provided by green spaces on human well-being in dispersed urban areas is a key challenge for sustainable spatial development in Europe. This article presents a methodology that allows for the comparison of the potential of
Wandl, Alexander
core   +2 more sources