Results 111 to 120 of about 9,979 (246)

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Repositorios documentales y la iniciativa de archivos abiertos en Latinoamérica

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2008
Hasta la fecha existen muy pocos estudios sobre la realidad de los repositorios documentales y bibliotecas digitales latinoamericanas, adicionalmente son muy escasos los estudios sobre la implantación de la iniciativa de archivos abiertos y el protocolo ...
Gómez Dueñas, Laureano Felipe
doaj  

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals. [PDF]

Arch Toxicol
Henderson CJ, McLaren AW, MacLeod AK, Lin D, Cameron AR, Chatham LR, Moggs J, Inesta-Vaquera F, Thomson JP, Meehan RR, Chakravarty P, Schwarz M, Roland Wolf C.   +12 more
europepmc   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Implementation science in global paediatric oncology: a scoping review protocol. [PDF]

BMJ Open
van Tinteren L, Klootwijk L, Duffy C, Alcasabas AP, Naheed A, Chelva MP, Coe MM, Forestier M, Huibers M, Irazola VE, Ket JCF, Malone S, Mahendradhata Y, Afungchwi GM, Njuguna F, Ortiz R, Schilstra C, Agulnik A, Heine M.   +18 more
europepmc   +1 more source

Die Open Archive Initiative

, 2003
Klotz-Berendes, Bruno, Müller, Uwe
openaire   +2 more sources

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Building an open infrastructure for molecular neuroimaging: Standards and tools from the OpenNeuroPET initiative. [PDF]

J Cereb Blood Flow Metab
Ganz M, Norgaard M, Pernet C, Matheson GJ, Galassi A, Ceballos E, Bilgel M, Eierud C, Gonzalez-Escamilla G, Wighton P, Markiewicz CJ, Hardcastle N, Buckholtz J, Blair R, Greve DN, Thomas AG, Poldrack RA, Calhoun V, Innis RB, Knudsen GM.   +19 more
europepmc   +1 more source