Results 71 to 80 of about 306,323 (300)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Beyond Harvesting: Digital Library Components as OAI Extensions [PDF]

, 2002
Reusability always has been a controversial topic in Digital Library (DL) design. While componentization has gained momentum in software engineering in general, there has not yet been broad DL standardization in component interfaces.
Fox, Edward A., Suleman, Hussein
core  

Die Open Archives Initiative (Vortrag)

, 2002
Nachdem vor zwei Jahren die Open Archives Initiative die Protokollversion 1.0 veröffentlicht hat, wurde im Juni 2002 nach ausführlichen Test die Version 2.0 veröffentlicht, die eine stabile Basis für die Zukunft sein soll. Die Erfolgsbilanz von OAI weist weltweit inzwischen mehr als 70 registrierte Archive nach.
openaire   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Science Metadata Management, Interoperability and Data Citations of the National Institute of Polar Research, Japan

Data Science Journal, 2018
The Polar Data Centre (PDC) of the National Institute of Polar Research (NIPR) has a responsibility to manage polar science data as part of the National Antarctic Data Centre and the Science Committee on Antarctic Research. During the International Polar
M. Kanao, M. Okada, J. Friddell, A. Kadokura   +3 more
doaj   +1 more source

Software DSpace

Conci, 2020
Investigação que visa elencar características básicas que compõem o pacote de software DSpace no contexto dos repositórios institucionais. Pontua temas essenciais para a pesquisa, sendo: comunicação científica, Iniciativa de Arquivos Abertos, Movimento ...
Marilete da Silva Pereira, Márcio Bezerra da Silva   +1 more
doaj   +1 more source

The Open Archives Initiative Object Reuse and Exchange (OAI-ORE)

, 2007
The Open Archives Initiative Object Reuse and Exchange (OAI-ORE) is a new collaborative international initiative, funded for the next 2 years by the Mellon Foundation, focusing on an interoperability framework for the exchange of information about ...
Hunter, Jane
core  

Paradigm change in scientific communication [PDF]

, 2002
The current pattern of scholarly publishing goes through times of dramatic changes. The model of open archives is presently being developed in several central countries. The aim of this initiative is to facilitate the efficient dissemination of scholarly
Arias, Olga Margarita, Gómez, Nancy Diana   +1 more
core   +2 more sources

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Informação científica: proposta de um novo modelo para o Brasil

Ciência da Informação, 2006
O acesso à informação científica tem sido um grande desafio para países em desenvolvimento como o Brasil. Com a crise dos periódicos, surgida em função dos altos custos na manutenção das assinaturas das revistas científicas, o acesso à informação ...
Hélio Kuramoto
doaj