Results 91 to 100 of about 5,277,748 (267)

Open Data Interoperability

open access: yes, 2018
Semantic technologies enable open data interoperability beyond the point of pure format and structure alignment.
Charalabidis, Yannis (author)   +5 more
openaire   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Two Tests for Quantifying Aided Hearing at Low- and High-Input Levels

open access: yesTrends in Hearing
Under- and overamplification of sound is a common problem in hearing aid fitting. This paper describes the implementation of two new variants of the hearing in noise test for quantifying aided hearing at the lower and upper ends of the range of everyday ...
Carl Pedersen   +4 more
doaj   +1 more source

L’universo delle risorse culturali: lampi di genio e azioni concrete. Lightning talks presentati al Convegno AIB CILW 2016

open access: yesAIB Studi, 2017
Sono raccolti sei dei sette lightning talks presentati al Convegno AIB CILW 2016, nell’ambito della sessione aperta al contributo di qualunque studioso delle tematiche proposte nell’incontro.
Gruppo di studio AIB CILW
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Old wine, new bottle? Principi e metodi per una reale innovazione nelle prospettive LIS. Il parere di Marshall Breeding, Mauro Guerrini, David Weinberger, Paul Gabriele Weston, Maja Žumer

open access: yesAIB Studi, 2015
Il saggio è costituito da interviste a Marshall Breeding, Mauro Guerrini, David Weinberger, Paul Gabriele Weston e Maja Žumer, realizzate ponendo tre domande a queste figure riconosciute a livello internazionale. Tramite questo saggio il Gruppo di studio
Gruppo di studio AIB CILW
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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