Results 101 to 110 of about 5,277,748 (267)

The importance of quality of health campaign information for outcome evaluation. A case study from Guinea-Bissau and Bangladesh

Vaccine: X
Background: Numerous national health intervention campaigns, e.g. supplementary immunization campaigns/activities (SIAs), have been conducted in low- and middle-income countries (LMIC) in the last decades. These campaigns are rarely evaluated for overall
Sebastian Nielsen, Sören Möller, Christine Stabell Benn, Peter Aaby   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Open Data Environment

, 2007
This talk will focus on metadata and open data environments. It will highlight the value of metadata and outline the challenges of raising support and investment for metadata management frameworks. It will also relate the importance of high quality metadata in the context of the international research communities and the need to coordinate efforts in ...
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Hydrodynamic interaction in a confined corner: a CFD study of flow and force behavior around a circular cylinder

Journal of Engineering and Applied Science
The current study explores the hydrodynamic interaction between corner walls consisting of two perpendicular surfaces and a circular cylinder, a configuration of engineering relevance that is relatively less explored.
Yinghui Sun, Zhaowei Zhang
doaj   +1 more source

Open Data Science

, 2018
The increasing openness of data, methods, and collaboration networks has created new opportunities for research, citizen science, and industry. Whereas openly licensed scientific, governmental, and institutional data sets can now be accessed through programmatic interfaces, compressed archives, and downloadable spreadsheets, realizing the full ...
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The effectiveness of the Fracture Risk Evaluation Model (FREM) in predicting major osteoporotic fractures and hip fractures: A register-based cohort study

Bone Reports, 2020
Michael Kriegbaum Skjødt, Sören Möller, Mette Bliddal, Nana Hyldig, Jens Søndergaard, Bo Abrahamsen, Katrine Hass Rubin   +6 more
doaj   +1 more source